14495-13-7

Usage

Uses

Used in Organic Chemistry:
Bis(quinolin-8-olato-N1,O8)manganese is used as a catalyst for various organic chemical reactions, particularly in the context of oxidation reactions. Its ability to efficiently promote oxidation processes makes it a valuable tool in the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Applications:
Bis(quinolin-8-olato-N1,O8)manganese has been studied for its potential in pharmaceutical applications due to its unique chemical properties. It may be utilized in the development of new drugs or drug delivery systems.
Used in Material Development:
Due to its unique chemical properties, bis(quinolin-8-olato-N1,O8)manganese is also being explored for its potential in the development of novel materials, which could have various applications in different industries.

Upstream product

• 148-24-3 8-quinolinol 
• 638-38-0 manganese(II) acetate 
• 6156-78-1 manganese (II) acetate tetrahydrate 
• 32270-87-4 Mn(C₉H₆NO)2(H₂O)2 

Downstream Products

• 148-24-3 8-quinolinol 
• 34557-54-5 methane 

Relevant academic research and scientific papers

Sonochemical synthesis and electrogenerated chemiluminescence properties of 8-hydroxyquinoline manganese (Mnq2) nanobelts

8-Hydroxyquinoline manganese (Mnq2) nanobelts with width of 500 nm and length of 2-4 μm have been synthesized by a facile sonochemical route. The composition, morphology and size of the as-prepared sample were confirmed by elemental analysis (EA), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and field-emission scanning electron microscopy (FE-SEM). The reaction parameters, such as the mole ratio of reactants and the concentration of ethylene glycol, play an important part in the morphology of the final product. The electrogenerated chemiluminescence (ECL) properties of the Mnq2 sample with different morphologies have also been investigated. The ECL spectra show that the Mnq2 nanobelts exhibited excellent electrogenerated chemiluminescence (ECL) behavior.

Manganese-52: applications in cell radiolabelling and liposomal nanomedicine PET imaging using oxine (8-hydroxyquinoline) as an ionophore

The ionophore 8-hydroxyquinoline (oxine) has been used to radiolabel cells and liposomal medicines with 111In and, more recently, 89Zr, for medical nuclear imaging applications. Oxine has also shown promising ionophore activity for the positron-emitting radionuclide 52Mn that should allow imaging of labelled cells and nanomedicines for long periods of time (>14 days). However, to date, the radiometal complex formed and its full labelling capabilities have not been fully characterised. Here, we provide supporting evidence of the formation of [52Mn]Mn(oxinate)2 as the metastable complex responsible for its ionophore activity. The cell labelling properties of [52Mn]Mn(oxinate)2 were investigated with various cell lines. The liposomal nanomedicine, DOXIL (Caelyx) was also labelled with [52Mn]Mn(oxinate)2 and imaged in vivo using PET imaging. [52Mn]Mn(oxinate)2 was able to label various cell lines with moderate efficiency (15-53%), however low cellular retention of 52Mn (21-25% after 24 h) was observed which was shown not to be due to cell death. PET imaging of [52Mn]Mn-DOXIL at 1 h and 24 h post-injection showed the expected pharmacokinetics and biodistribution of this stealth liposome, but at 72 h post-injection showed a profile matching that of free 52Mn, consistent with drug release. We conclude that oxine is an effective ionophore for 52Mn, but high cellular efflux of the isotope limits its use for prolonged cell tracking. [52Mn]Mn(oxinate)2 is effective for labelling and tracking DOXIL in vivo. The release of free radionuclide after liposome extravasation could provide a non-invasive method to monitor drug release in vivo.

Novel α-ketoesters from β-diketones via a vanadium-mediated tandem transformation under an oxygen atmosphere

Novel α-ketoesters were conveniently synthesized from acetylacetone and analogs via a vanadium-mediated one-pot tandem process. These advanced α-ketoesters could be selectively prepared under additive-free, mild conditions, viz., 1 atm O2 pressure and 50-80°C. DFT calculations were performed to provide insights into the detailed mechanism of the tandem transformation.

Design, synthesis, and antifungal evaluation of 8-hydroxyquinoline metal complexes against phytopathogenic fungi

Phytopathogenic fungal infections have become a major threat to agricultural production, food security, and human health globally, and novel antifungal agents with simple chemical scaffolds and high efficiency are needed. In this study, we designed and synthesized 38 8-hydroxyquinoline metal complexes and evaluated their antifungal activities. The results showed that most of the tested compounds possessed remarkable in vitro antifungal activity. Especially, compound 1e exhibited the highest antifungal potency among all target compounds, with EC50 values of 0.0940, 0.125, 2.95, and 5.96 μg/mL, respectively, against Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium graminearum, and Magnaporthe oryzae. Preliminary mechanistic studies had shown that compound 1e might cause mycelial abnormalities of S. sclerotiorum, cell membrane permeability changes, leakage of cell contents, and inhibition of sclerotia formation and germination. Moreover, the results of in vivo antifungal activity of compound 1e against S. sclerotiorum showed that 1e possessed higher curative effects than that of the positive control azoxystrobin. Therefore, compound 1e is expected to be a novel leading structure for the development of new antifungal agents.

Agricultural bactericide with bactericidal activity and application thereof

The invention belongs to the field of agriculture and discloses an agricultural bactericide with bactericidal activity and application thereof. The agricultural bactericide with bactericidal activityis a manganese-8-HQ (8-hydroxyquionline) chelate prepared by chelating metal manganese and 8-HQ. With good bactericidal activity, the agricultural bactericide with bactericidal activity can be widelyapplied to treating diseases of the overground parts of rice, wheat, vegetables and fruit trees. Due to be safe to growth of crops, the manganese-8-HQ chelate can be applied to coating and soaking crop seeds to promote rapid seed germination and seedling growth with protection over the seeds and seedlings from diseases .