14495-13-7

Basic information

• Product Name: bis(quinolin-8-olato-N1,O8)manganese
• Synonyms: Bis(quinolin-8-olato-N1,O8)manganese; NSC 615011; NSC 82408; manganese(2+) 8-hydroxyoctahydro-2H-quinolin-1-ide 8-hydroxy-2H-quinolin-1-ide (1:1:1); quinolin-8-ol - manganese (2:1)
• CAS NO: 14495-13-7
• Molecular Formula: C₁₈H₁₂MnN₂O₂
• Molecular Weight: 345.254
• EINECS: 238-502-9
• Mol File: 14495-13-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 267°C at 760 mmHg
• Flash Point: 143.1°C
• Vapor Pressure: 0.00508mmHg at 25°C
• CAS DataBase Reference: bis(quinolin-8-olato-N1,O8)manganese(CAS DataBase Reference)
• NIST Chemistry Reference: bis(quinolin-8-olato-N1,O8)manganese(14495-13-7)
• EPA Substance Registry System: bis(quinolin-8-olato-N1,O8)manganese(14495-13-7)

Safety Data

• Hazardous Substances Data: 14495-13-7(Hazardous Substances Data)

Usage

General Description

Bis(quinolin-8-olato-N1,O8)manganese is a chemical compound that consists of two quinolin-8-olato ligands bonded to a central manganese atom. It is commonly used as a catalyst in organic chemical reactions, particularly in the context of oxidation reactions. bis(quinolin-8-olato-N1,O8)manganese is known for its ability to efficiently promote various oxidation processes, making it a valuable tool in the synthesis of a wide range of organic compounds. Additionally, it has been studied for its potential in pharmaceutical applications and in the development of novel materials due to its unique chemical properties. Overall, bis(quinolin-8-olato-N1,O8)manganese is a versatile and important compound in the field of organic chemistry and catalysis.

Upstream product

• 32270-87-4 Mn(C₉H₆NO)2(H₂O)2 
• 148-24-3 8-quinolinol 
• 638-38-0 manganese(II) acetate 
• 6156-78-1 manganese (II) acetate tetrahydrate 

Downstream Products

• 148-24-3 8-quinolinol 
• 34557-54-5 methane 

Relevant articles and documents

Manganese-52: applications in cell radiolabelling and liposomal nanomedicine PET imaging using oxine (8-hydroxyquinoline) as an ionophore

The ionophore 8-hydroxyquinoline (oxine) has been used to radiolabel cells and liposomal medicines with 111In and, more recently, 89Zr, for medical nuclear imaging applications. Oxine has also shown promising ionophore activity for the positron-emitting radionuclide 52Mn that should allow imaging of labelled cells and nanomedicines for long periods of time (>14 days). However, to date, the radiometal complex formed and its full labelling capabilities have not been fully characterised. Here, we provide supporting evidence of the formation of [52Mn]Mn(oxinate)2 as the metastable complex responsible for its ionophore activity. The cell labelling properties of [52Mn]Mn(oxinate)2 were investigated with various cell lines. The liposomal nanomedicine, DOXIL (Caelyx) was also labelled with [52Mn]Mn(oxinate)2 and imaged in vivo using PET imaging. [52Mn]Mn(oxinate)2 was able to label various cell lines with moderate efficiency (15-53%), however low cellular retention of 52Mn (21-25% after 24 h) was observed which was shown not to be due to cell death. PET imaging of [52Mn]Mn-DOXIL at 1 h and 24 h post-injection showed the expected pharmacokinetics and biodistribution of this stealth liposome, but at 72 h post-injection showed a profile matching that of free 52Mn, consistent with drug release. We conclude that oxine is an effective ionophore for 52Mn, but high cellular efflux of the isotope limits its use for prolonged cell tracking. [52Mn]Mn(oxinate)2 is effective for labelling and tracking DOXIL in vivo. The release of free radionuclide after liposome extravasation could provide a non-invasive method to monitor drug release in vivo.

Design, synthesis, and antifungal evaluation of 8-hydroxyquinoline metal complexes against phytopathogenic fungi

Phytopathogenic fungal infections have become a major threat to agricultural production, food security, and human health globally, and novel antifungal agents with simple chemical scaffolds and high efficiency are needed. In this study, we designed and synthesized 38 8-hydroxyquinoline metal complexes and evaluated their antifungal activities. The results showed that most of the tested compounds possessed remarkable in vitro antifungal activity. Especially, compound 1e exhibited the highest antifungal potency among all target compounds, with EC50 values of 0.0940, 0.125, 2.95, and 5.96 μg/mL, respectively, against Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium graminearum, and Magnaporthe oryzae. Preliminary mechanistic studies had shown that compound 1e might cause mycelial abnormalities of S. sclerotiorum, cell membrane permeability changes, leakage of cell contents, and inhibition of sclerotia formation and germination. Moreover, the results of in vivo antifungal activity of compound 1e against S. sclerotiorum showed that 1e possessed higher curative effects than that of the positive control azoxystrobin. Therefore, compound 1e is expected to be a novel leading structure for the development of new antifungal agents.