1449578-44-2Relevant academic research and scientific papers
Syntheses of prodrug-type 2′-O-methyldithiomethyl oligonucleotides modified at natural four nucleoside residues and their conversions into natural 2′-hydroxy oligonucleotides under reducing condition
Hayashi, Junsuke,Ochi, Yosuke,Morita, Yasuyuki,Soubou, Katsuma,Ohtomo, Yuhei,Nishigaki, Misa,Tochiyama, Yuko,Nakagawa, Osamu,Wada, Shun-ichi,Urata, Hidehito
, p. 5838 - 5844 (2018/11/23)
We previously reported that reducing-environment-responsive prodrug-type small interfering RNA (siRNA) bearing 2′-O-methyldithiomethyl (2′-O-MDTM) uridine exhibits efficient knockdown activity and nuclease resistance. In this report, we describe the prepa
A post-synthetic approach for the synthesis of 2′-O- methyldithiomethyl-modified oligonucleotides responsive to a reducing environment
Ochi, Yosuke,Nakagawa, Osamu,Sakaguchi, Katsunori,Wada, Shun-Ichi,Urata, Hidehito
, p. 7620 - 7622 (2013/08/28)
Based on a novel concept, a Reducing-Environment-Dependent Uncatalyzed Chemical Transforming RNA, REDUCT RNA , we established a post-synthetic approach for the synthesis of 2′-O-methyldithiomethyl- modified oligonucleotides from 2′-O-(2,4,6-trimethoxybenzylthiomethyl)- oligonucleotides by treatment with dimethyl(methylthio)sulfonium tetrafluoroborate. 2′-O-methyldithiomethyl oligonucleotides were easily converted into 2′-hydroxy oligonucleotides under reducing conditions, such as those found in the intracellular environment. This journal is The Royal Society of Chemistry.
