1449602-29-2

Upstream product

• 1449602-36-1 tert-butyl (1S,4S)-4-[4-(benzyloxy)benzyl]-3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate 
• 124-41-4 sodium methylate 
• 836-42-0 4-benzyloxybenzyl chloride 
• 367966-45-8 (2S,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester 

Downstream Products

• 1449602-52-1 methyl O-benzyl-2-(α-cyanomethyl)-tyrosinate 
• 1449602-54-3 methyl (2S)-2-[4-(benzyloxy)benzyl]-5-oxopiperazine-2-carboxylate 
• 1449602-39-4 1-tert-butyl 2-methyl (2S)-2-[4-(benzyloxy)benzyl]-4-oxopyrrolidine-1,2-dicarboxylate 

Relevant academic research and scientific papers

Synthetic studies on α,α-disubstituted amino acids employing (2S,4R)-4-hydroxyproline as the chiral pool: Preparation of methyl o-benzyl-2-(α-cyanomethyl)-D-tyrosinate and dimethyl 2-(4-hydroxybenzyl)- L-aspartate

Methyl O-benzyl-2-(α-cyanomethyl)-D-tyrosinate and dimethyl 2-(4-hydroxybenzyl)-L-aspartate were synthesized starting from (2S,4R)-4-hydroxyproline Via Beckmann fragmentation of the corresponding oxime tosylate.