1449650-38-7

Basic information

• Product Name: 2-methyl-10-tosyl-2,4,5,10-tetrahydropyrazolo[3,4-a]carbazole
• Synonyms: 2-methyl-10-tosyl-2,4,5,10-tetrahydropyrazolo[3,4-a]carbazole
• CAS NO: 1449650-38-7
• Molecular Weight: 377.467
• Mol File: 1449650-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-10-tosyl-2,4,5,10-tetrahydropyrazolo[3,4-a]carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-10-tosyl-2,4,5,10-tetrahydropyrazolo[3,4-a]carbazole(1449650-38-7)
• EPA Substance Registry System: 2-methyl-10-tosyl-2,4,5,10-tetrahydropyrazolo[3,4-a]carbazole(1449650-38-7)

Safety Data

• Hazardous Substances Data: 1449650-38-7(Hazardous Substances Data)

Upstream product

• 1449650-33-2 9-tosyl-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 3456-99-3 1-oxo-2,3,4,9-tetrahydrocarbazole 
• 1687-48-5 cyclohexane-1,2-dione mono(phenylhydrazone) 
• 1449650-34-3 (Z)-2-(hydroxymethylene)-9-tosyl-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 1449650-36-5 10-tosyl-2,4,5,10-tetrahydropyrazolo[3,4-a]carbazole 
• 74-88-4 methyl iodide 

Relevant articles and documents

A novel necroptosis inhibitor - Necrostatin-21 and its SAR study

An initial structure-activity relationship study of the novel necroptosis inhibitor Nec-21 was described. Any changes of the tetracyclic scaffold were detrimental for the activity. Introduction of a substituent to 7 or 8 position (e.g., cyano or methoxy group, respectively), would increase the activity. The 7 and 8-position disubstituted compound 17b was 35-fold as potent as the lead, while EC50 reached 14 nM.