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2,3,4,9-Tetrahydro-1H-carbazol-1-one is a carbazole derivative with the molecular formula C13H13NO and a molecular weight of 199.25 g/mol. It features a tetrahydro-1H-carbazol-1-one core structure, which is a carbazole ring system fused with a cyclic ketone group. This pale yellow solid has a melting point of 217-218°C and is widely used in various industrial applications, including dyes, pigments, and pharmaceuticals. It serves as an intermediate in the synthesis of pharmaceuticals and agrochemicals and has been studied for its potential biological activities and pharmacological properties.

3456-99-3

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3456-99-3 Usage

Uses

Used in Pharmaceutical Industry:
2,3,4,9-Tetrahydro-1H-carbazol-1-one is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological activities and pharmacological properties.
Used in Agrochemical Industry:
2,3,4,9-Tetrahydro-1H-carbazol-1-one is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective and safe agricultural products.
Used in Dye and Pigment Industry:
2,3,4,9-Tetrahydro-1H-carbazol-1-one is used as a component in the production of dyes and pigments, providing color and stability to various materials and products.

Check Digit Verification of cas no

The CAS Registry Mumber 3456-99-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,5 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3456-99:
(6*3)+(5*4)+(4*5)+(3*6)+(2*9)+(1*9)=103
103 % 10 = 3
So 3456-99-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H11NO/c14-11-7-3-5-9-8-4-1-2-6-10(8)13-12(9)11/h1-2,4,6,13H,3,5,7H2

3456-99-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3,4,9-tetrahydrocarbazol-1-one

1.2 Other means of identification

Product number -
Other names 1,2,3,4-tetrahydrocarbazole-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3456-99-3 SDS

3456-99-3Relevant articles and documents

Convenient and efficient synthesis of 1-oxo-1,2,3,4-tetrahydrocarbazoles via Fischer indole synthesis

Sheng, Rong,Shen, Li,Chen, You-Qin,Hu, Yong-Zhou

body text, p. 1120 - 1127 (2009/09/08)

A convenient synthesis of 1-oxo-1,2,3,4-tetra-hydrocarbazoles has been developed by reaction of 2-aminocyclohexanone hydrochlorides with various phenylhydrazine hydrochlorides via Fischer indole synthesis under mild conditions. The method is more satisfac

Synthesis and In-vitro antitumor activities of some mannich bases of 9-alkyl-1,2,3,4-tetrahydrocarbazole-1-ones

Chen, Jing,Lou, Jianshu,Liu, Tao,Wu, Ru,Dong, Xiaowu,He, Qiaojun,Yang, Bo,Hu, Yongzhou

experimental part, p. 165 - 172 (2009/05/27)

A novel series of 2-substituted aminomethyl-9-alkyl-1,2,3,4- tetrahydrocarbazole-1-ones 5a-q was synthesized via aminomethylation of 9-alkyl-1,2,3,4-tetrahydrocarbazole-1-ones 4a-e with hydrochlorides of the respective amines 6a-m. The structures of these newly synthesized compounds were characterized by 1H-NMR, MS, and elemental analysis. All the compounds were tested for their cytotoxic activity in vitro against four human tumor cell lines including human non-small lung cancer cells (A549), human gastric adenocarcinoma (SGC), human colon cancer cell (HCT116), human myeoloid leukemia cells (K562), and one multi-drug resistant subline (KB- VCR). Most compounds showed moderate to potent cytotoxic activity against the tested cell lines. Preliminary mechanism research indicated that the most promising compound, 2-diethyl-aminomethyl-9-methyl-1,2,3,4-tetrahydrocarbazole-1-one 5c, exhibited a potential inhibitory effect against microtubule. 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Molecular structure and reactivity of the 1,2-dihydrocarbazol-4(3H)-one: X-ray crystal structure of N-methyl and N-(p-methylbenzenesulfonyl) derivatives

Rodriguez, Jose Gonzalo,Valle, Celestina del,Esteban-Calderon, Carmen,Martinez-Ripoll, Martin

, p. 249 - 258 (2007/10/02)

Synthesis and reactivity analysis of the 1,2-dihydrocarbazol-4(3H)-one, and the N-methyl, N-tosyl and 2,2-dimethyl derivatives have been carried out.Molecular structures of the N-methyl and N-tosyl derivatives have been analyzed by X-ray diffraction.Crystals of the N-methyl derivative are monoclinic, space group P21/c, a=8.868(1), b=16.652(1), c=7.5440(4) Angstroem, β=113.657(3).Crystals of the N-tosyl derivative are monoclinic, P21/c, a=12.0016(3), b=8.9178(2), c=16.0485(4) Angstroem, β=104.372(2).An extended conjugation from the carbonyl group to the nitrogen atom and an envelope conformation for the common cyclohexenone fragment are evident in both cases.Oximation and Beckmann rearrangement, and etherification of the carbonyl group is reported.KEY WORDS: Synthesis, reactivity, tetrahydrocarbazol-4-one.

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