3456-99-3

Basic information

• Product Name: 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
• Synonyms: RARECHEM AK MA K050;1,2,3,4-TETRAHYDROCARBAZOLE-1-ONE;2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE;AKOS BC-0293;3,4-DIHYDROCARBAZOL-1(2H)-ONE;2,3,4,9-tetrahydrocarbazol-1-one;3,4-dihydro-2H-carbazol-1(9H)-one
• CAS NO: 3456-99-3
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22
• Mol File: 3456-99-3.mol

Chemical Properties

• Melting Point: 164-165
• Boiling Point: 386.3°Cat760mmHg
• Flash Point: 194.5°C
• Appearance: /
• Density: 1.275g/cm³
• Vapor Pressure: 3.59E-06mmHg at 25°C
• Refractive Index: 1.689
• Storage Temp.: 2-8°C
• PKA: 15.13±0.20(Predicted)
• CAS DataBase Reference: 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE(3456-99-3)
• EPA Substance Registry System: 2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE(3456-99-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3456-99-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3,4,9-Tetrahydro-1H-carbazol-1-one is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological activities and pharmacological properties.
Used in Agrochemical Industry:
2,3,4,9-Tetrahydro-1H-carbazol-1-one is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective and safe agricultural products.
Used in Dye and Pigment Industry:
2,3,4,9-Tetrahydro-1H-carbazol-1-one is used as a component in the production of dyes and pigments, providing color and stability to various materials and products.

InChI:InChI=1/C12H11NO/c14-11-7-3-5-9-8-4-1-2-6-10(8)13-12(9)11/h1-2,4,6,13H,3,5,7H2

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 6946-05-0 2-aminocyclohexanone hydrochloride 
• 942-01-8 1,2,3,4-tetrahydrocarbazole 
• 64-17-5 ethanol 
• 100-63-0 phenylhydrazine 
• 533-60-8 cyclohexanone-2-ol 

Downstream Products

• 22298-59-5 2,3,4,9-tetrahydro-carbazol-1-one phenylhydrazone 
• 101735-06-2 2,3,4,9-tetrahydro-carbazol-1-one-(2,4-dinitro-phenylhydrazone) 
• 1485-19-4 9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 1592-62-7 1-hydroxy-1,2,3,4-tetrahydrocarbazole 
• 59514-18-0 6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 4828-96-0 cis-2,3,4,4a,9,9a-hexahydro-1H-carbazole 
• 22298-67-5 N-benzyl-2,3,4,9-tetrahydrocarbazol-1-one 
• 1021186-01-5 C₂₀H₁₇NO₃ 

Relevant articles and documents

Convenient and efficient synthesis of 1-oxo-1,2,3,4-tetrahydrocarbazoles via Fischer indole synthesis

A convenient synthesis of 1-oxo-1,2,3,4-tetra-hydrocarbazoles has been developed by reaction of 2-aminocyclohexanone hydrochlorides with various phenylhydrazine hydrochlorides via Fischer indole synthesis under mild conditions. The method is more satisfac

Synthesis and In-vitro antitumor activities of some mannich bases of 9-alkyl-1,2,3,4-tetrahydrocarbazole-1-ones

A novel series of 2-substituted aminomethyl-9-alkyl-1,2,3,4- tetrahydrocarbazole-1-ones 5a-q was synthesized via aminomethylation of 9-alkyl-1,2,3,4-tetrahydrocarbazole-1-ones 4a-e with hydrochlorides of the respective amines 6a-m. The structures of these newly synthesized compounds were characterized by 1H-NMR, MS, and elemental analysis. All the compounds were tested for their cytotoxic activity in vitro against four human tumor cell lines including human non-small lung cancer cells (A549), human gastric adenocarcinoma (SGC), human colon cancer cell (HCT116), human myeoloid leukemia cells (K562), and one multi-drug resistant subline (KB- VCR). Most compounds showed moderate to potent cytotoxic activity against the tested cell lines. Preliminary mechanism research indicated that the most promising compound, 2-diethyl-aminomethyl-9-methyl-1,2,3,4-tetrahydrocarbazole-1-one 5c, exhibited a potential inhibitory effect against microtubule. 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Molecular structure and reactivity of the 1,2-dihydrocarbazol-4(3H)-one: X-ray crystal structure of N-methyl and N-(p-methylbenzenesulfonyl) derivatives

Synthesis and reactivity analysis of the 1,2-dihydrocarbazol-4(3H)-one, and the N-methyl, N-tosyl and 2,2-dimethyl derivatives have been carried out.Molecular structures of the N-methyl and N-tosyl derivatives have been analyzed by X-ray diffraction.Crystals of the N-methyl derivative are monoclinic, space group P21/c, a=8.868(1), b=16.652(1), c=7.5440(4) Angstroem, β=113.657(3).Crystals of the N-tosyl derivative are monoclinic, P21/c, a=12.0016(3), b=8.9178(2), c=16.0485(4) Angstroem, β=104.372(2).An extended conjugation from the carbonyl group to the nitrogen atom and an envelope conformation for the common cyclohexenone fragment are evident in both cases.Oximation and Beckmann rearrangement, and etherification of the carbonyl group is reported.KEY WORDS: Synthesis, reactivity, tetrahydrocarbazol-4-one.