1449657-41-3

Upstream product

• 2434-53-9 6-amino-1-methyluracil 
• 6972-78-7 6-amino-1-methyl-5-nitrosouracil 
• 6972-82-3 5,6-diamino-1-methyluracil 
• 1449657-39-9 7-(2-cyanobenzyl)-8-hydroxymethyl-3-methylxanthine 
• 27038-81-9 8-(hydroxymethyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione 

Downstream Products

• 1449657-49-1 C₂₆H₂₃N₇O₅S 
• 1450975-75-3 C₂₉H₂₉N₉O₂ 
• 1450975-76-4 C₃₀H₃₁N₉O₂ 
• 1450975-78-6 C₂₅H₂₂N₈O₂ 
• 1450975-74-2 C₂₇H₂₇N₉O₂ 

Relevant academic research and scientific papers

Synthesis and biological evaluation of xanthine derivatives on dipeptidyl peptidase 4

A series of xanthine derivatives in which a methylene was inserted at position 8 of xanthine scaffold was synthesized and evaluated as inhibitors of dipeptidyl peptidase 4 (DPP-4) for the treatment of type 2 diabetes. As the results of structure-activity relationship (SAR) study of the series, the compounds with 4-methylquinazoline- 2-yl-methyl group at N-1 position and 2-aminoethylaminomethyl group gave better activities. Compounds H4 and H9 showed good DPP-4 inhibition and more than 100-fold selectivity over DPP-7 and DPP-8.