1450975-75-3Relevant academic research and scientific papers
Synthesis and biological evaluation of xanthine derivatives on dipeptidyl peptidase 4
Lin, Kuaile,Cai, Zhengyan,Wang, Fei,Zhang, Wei,Zhou, Weicheng
, p. 477 - 482 (2013/05/22)
A series of xanthine derivatives in which a methylene was inserted at position 8 of xanthine scaffold was synthesized and evaluated as inhibitors of dipeptidyl peptidase 4 (DPP-4) for the treatment of type 2 diabetes. As the results of structure-activity relationship (SAR) study of the series, the compounds with 4-methylquinazoline- 2-yl-methyl group at N-1 position and 2-aminoethylaminomethyl group gave better activities. Compounds H4 and H9 showed good DPP-4 inhibition and more than 100-fold selectivity over DPP-7 and DPP-8.
