1450-86-8

Usage

Uses

Used in Pharmaceutical Industry:
4(1H)-Pyrimidinethione (9CI) is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its ability to inhibit specific enzymes and metabolic pathways makes it a promising candidate for the development of drugs targeting a range of diseases, including cancer and diabetes.
Used in Dye Industry:
In the dye industry, 4(1H)-Pyrimidinethione (9CI) serves as an essential component in the production of different types of dyes. Its chemical structure allows for the creation of vibrant and stable colorants used in various applications, such as textiles, plastics, and printing inks.
Used in Agrochemical Industry:
4(1H)-Pyrimidinethione (9CI) is employed in the agrochemical sector for its antimicrobial properties. It is used as an active ingredient in anti-fungal and anti-dandruff shampoos, helping to combat fungal infections and promote healthy hair and scalp.
Used in Rubber Chemical Industry:
In the rubber chemical industry, 4(1H)-Pyrimidinethione (9CI) is used in the production of various rubber chemicals. Its unique chemical properties contribute to the development of rubber products with enhanced performance characteristics, such as improved durability and resistance to environmental factors.
Overall, 4(1H)-Pyrimidinethione (9CI) is a versatile chemical compound with a wide range of applications across different industries. Its ability to inhibit enzymes and metabolic pathways, along with its antimicrobial properties, makes it a valuable asset in the development of new products and treatments for various diseases and conditions.

Upstream product

• 179051-78-6 4-chloropyrimidine hydrochloride 
• 17356-08-0 thiourea 
• 51953-17-4 Pyrimidin-4-ol 

Downstream Products

• 1450-86-8 4-mercaptopyrimidine 
• 71208-64-5 4-(N-oxidopyridyl-3-methyl)thiopyrimidine 

Relevant academic research and scientific papers

GAMMA SECRETASE INHIBITORS

Disclosed herein are compounds of Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containi

Heterocyclic compounds

Compounds of formula (I): STR1 wherein R1, R2 and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, halogen, haloalkyl, alkoxy, alkenoxy, alkoxyalkyl, haloalkoxy, alkylthio, cyano, nitro, amino, NR5 R6, hydroxy, acylamino, --CO2 R4, --O(CH2)m CO2 R4, phenyl, phenoxy, benzyl or benzyloxy, the phenyl group or phenyl moiety of the benzyl group being optionally substituted in the ring; or R2 and R3 when taken together form a 5- or 6-membered ring; m is 1 or 2; R4 and R6 are hydrogen or C1-4 alkyl; R5 is C1-4 alkyl; n is 0, 1 or 2; are useful as nematicides.

Artificial DNA base pair analogues

The present invention is directed to new artificial base pairs comprising complementary artificial purines and pyrimidines and methods of using artificial complementary base pairs.

Theoretical and Infrared Matrix Isolation Study of 4(3H)-Pyrimidinethione and 3(2H)-Pyridazinethione. Tautomerism and Phototautomerism

IR spectra of 4(3H)-pyrimidinethione and 3(2H)-pyridazinethione isolated in argon and nitrogen matrices are reported.The thiol and thione tautomeric forms of 4(3H)-pyrimidinethione were found in matrices in relative concentrations ca. 5:1.IR spectra of gaseous sample showed that the ratio of tautomers in matrices corresponds to the gas-phase tautomeric equilibrium.Only the thione form of 3(2H)-pyridazinethione was observed in matrices.UV-vis irradiation of the matrices caused the conversion ot the thione forms of the studied molecules into the thiol forms.The IR spectra of the thione and thiol tautomers were predicted theoretically a t SCF/3-21G* level, and a comparison ot the predicted and experimentally observed spectra enabled an assignment of most of the observed bands.