145038-61-5Relevant articles and documents
Enantioselective synthesis of (+)-(1R,2S)-allocoronamic acid
Alcaraz,Herrero,Marco,Fernandez-Alvarez,Bernabe
, p. 5605 - 5608 (1992)
The asymmetric synthesis of (+)-(1R,2S)-allocoronamic acid is reported. Diazomethane addition to (Z)-N-(tert-butoxycarbonyl)ethyldehydroalanyl-L-prolin-anhydride, easily prepared from (Z)-2-phenyl-4-propylidene-5(4H)-oxazolone and L-proline, gave in high diastereomeric excess the corresponding spiropyrazoline, which was transformed on photolysis and acid hydrolysis of the resulting spirocyclopropane, into (+)-(1R,2S)-1-amino-2-ethyl-cyclopropanecarboxylic acid.