145045-90-5

Upstream product

• 113661-76-0 5-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-t-butoxycarbonylpyrrol-2-ylmethylene>-4,4-dimethylpyrrolidin-2-one 
• 145045-86-9 t-butyl 1,2,3,10-tetrahydro-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1-thioxodipyrrin-9-carboxylate 
• 78815-40-4 Benzyl tert-butyl bromomalonate 

Downstream Products

• 145046-06-6 5-[5-[1-Benzyloxycarbonyl-meth-(E)-ylidene]-3,3-dimethyl-pyrrolidin-(2Z)-ylidenemethyl]-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 145046-07-7 C₄₆H₅₄N₄O₁₁ 
• 145045-93-8 Benzyl 13,17-bis-(2-methoxycarbonylethyl)-12,18-bis-(methoxycarbonylmethyl)-2,2,8,8-tetramethylisobacteriochlorin-5-carboxylate 
• 145045-92-7 3-{5-[5-[1-Benzyloxycarbonyl-meth-(E)-ylidene]-3,3-dimethyl-pyrrolidin-(2Z)-ylidenemethyl]-4-methoxycarbonylmethyl-1H-pyrrol-3-yl}-propionic acid methyl ester 

Relevant academic research and scientific papers

Synthetic Studies Relevant to Biosynthetic Research on Vitamin B12. Part 8. Synthesis of (+/-)-Faktor-I Octamethyl Ester

Several variations have been explored of the general synthesis of chlorins which uses a photochemical ring-closure of the macrocycle as the key step.This work leads to a synthesis of (+/-)-Faktor-I octamethyl ester, a chlorin which arises, in the free-acid form, by aromatisation of the mono-C-methylated intermediate on the biosynthetic pathway to vitamin B12.This synthesis confirms the structure of Faktor-I and allows labelled samples to be prepared.