78815-40-4Relevant academic research and scientific papers
Phase-transfer catalyzed enantioselective α-alkylation of α-acyloxymalonates: Construction of chiral α-hydroxy quaternary stereogenic centers
Ha, Min Woo,Choi, Sujee,Kim, Seek,Lee, Jun Young,Lee, Jae Kyun,Lee, Jeeyeon,Hong, Suckchang,Park, Hyeung-Geun
, p. 77427 - 77430 (2016)
The enantioselective synthesis of α-acyloxy-α-alkylmalonates was developed as an efficient method for producing chiral α-tertiary alcohols, which are potentially valuable intermediates in the synthesis of natural products and pharmaceuticals. The efficient enantioselective α-alkylation of diphenylmethyl tert-butyl α-acyloxymalonates was accomplished via phase-transfer catalysis in the presence of (S,S)-3,4,5-trifluorophenyl-NAS bromide to afford the corresponding α-acyloxy-α-alkylmalonates at high chemical (up to 99%) and optical (up to 93% ee) yields, which could be readily converted to versatile chiral intermediates with a chiral α-tertiary alcohol group.
Synthetic Studies Relevant to Biosynthetic Research on Vitamin B12. Part 10. Construction of the East and West Building Blocks for Synthesis of Isobacteriochlorins
Battersby, Alan R.,Block, Michael H.,Fookes, Christopher J. R.,Harrison, Peter J.,Henderson, Graeme B.,Leeper, Finian J.
, p. 2175 - 2188 (2007/10/02)
Studies with model compounds have led to the development of effective methods for (a) linking the pyrrolic rings to the reduced rings present in the isobacteriochlorin system (e.g. 4) and (b) for introducing the carbon at C-5 required to complete the macr
