1450621-80-3

Basic information

• Product Name: 2-(4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
• Synonyms: 2-(4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
• CAS NO: 1450621-80-3
• Molecular Weight: 456.431
• Mol File: 1450621-80-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol(1450621-80-3)
• EPA Substance Registry System: 2-(4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol(1450621-80-3)

Safety Data

• Hazardous Substances Data: 1450621-80-3(Hazardous Substances Data)

Upstream product

• 1450621-77-8 ethyl 2-[benzyl-[(2S)-2-(tert-butoxycarbonylamino)pent-4-ynoyl]amino]acetate 
• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 1450621-78-9 (3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione 
• 1450621-79-0 (3S)-1-benzyl-3-(2-propyn-1-yl)-piperazine 
• 1450620-25-3 (3S)-1-benzyl-3-(1-propyn-1-yl)piperazine 
• 2402-72-4 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 

Downstream Products

• 1450620-96-8 2-(4-((2S)-4-((6-chloro-3-pyridazinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1450620-95-7 2-(4-((2S)-4-((6-amino-3-pyridazinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1450621-10-9 2-(4-((2S)-4-((6-amino-5-bromo-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1450621-11-0 3-bromo-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinol 
• 1450621-14-3 2-amino-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridinecarbonitrile 
• 1450621-76-7 2-(4-((2S)-4-((2-amino-5-pyrimidinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1450620-19-5 1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-2-propanol 
• 1450621-12-1 C₂₁H₁₇BrClF₆N₃O₃S 
• 1361224-53-4 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1572928-68-7 tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate 

Relevant articles and documents

Nonracemic synthesis of GK-GKRP disruptor AMG-3969

A nonracemic synthesis of the glucokinase-glucokinase regulatory protein disruptor AMG-3969 (5) is reported. Key features of the synthetic approach are an asymmetric synthesis of the 2-alkynyl piperazine core via a base-promoted isomerization and a revised approach to the synthesis of the aminopyridinesulfonamide with an improved safety profile.

SULFONYL COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

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