Technology Process of 2-(4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
There total 6 articles about 2-(4-((2S)-4-benzyl-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos;
In
1,4-dioxane;
at 80 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C
2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
2.2: 0.17 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 65 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C
5.1: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 12 h / 80 °C
With
lithium aluminium tetrahydride; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; potassium tert-butylate; triethylamine; HATU; trifluoroacetic acid; sodium t-butanolate; ruphos;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 65 °C
2: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C
3: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 12 h / 80 °C
With
lithium aluminium tetrahydride; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; potassium tert-butylate; sodium t-butanolate; ruphos;
In
tetrahydrofuran; 1,4-dioxane;
