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1450666-80-4

(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone is a pharmaceutical compound with potential therapeutic effects. It consists of a pyrazinylphenyl moiety linked to a piperazine group, and a methanone functional group. (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone may have properties that make it suitable for use as a drug in the treatment of certain medical conditions, although further research is needed to fully understand its potential applications. The presence of the trifluoromethyl group in the molecule could also affect its physicochemical and pharmacological properties. Overall, the detailed study of the compound's structure and its biological activity could provide valuable insights for the development of novel medications.

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  • 1450666-80-4 Structure

  • Basic information

    1. Product Name: (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone
    2. Synonyms: (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone
    3. CAS NO:1450666-80-4
    4. Molecular Formula:
    5. Molecular Weight: 427.429
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1450666-80-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 568.7±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.321±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone(CAS DataBase Reference)
    10. NIST Chemistry Reference: (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone(1450666-80-4)
    11. EPA Substance Registry System: (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone(1450666-80-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1450666-80-4(Hazardous Substances Data)

1450666-80-4 Usage

Uses

Used in Pharmaceutical Industry:
(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone is used as a potential therapeutic agent for the treatment of certain medical conditions. Its unique molecular structure, which includes a pyrazinylphenyl moiety, a piperazine group, and a methanone functional group, may contribute to its pharmacological activity. The trifluoromethyl group present in the molecule could also influence its physicochemical properties, potentially enhancing its efficacy as a therapeutic agent.
Further research and development are required to fully understand the compound's potential applications and to optimize its use in the pharmaceutical industry. The study of its structure-activity relationship and biological activity could lead to the development of novel medications for various medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1450666-80-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,0,6,6 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1450666-80:
(9*1)+(8*4)+(7*5)+(6*0)+(5*6)+(4*6)+(3*6)+(2*8)+(1*0)=164
164 % 10 = 4
So 1450666-80-4 is a valid CAS Registry Number.

1450666-80-4Downstream Products

1450666-80-4Relevant articles and documents

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle

Le Manach, Claire,Nchinda, Aloysius T.,Paquet, Tanya,Gonzàlez Cabrera, Diego,Younis, Yassir,Han, Ze,Bashyam, Sridevi,Zabiulla, Mohammed,Taylor, Dale,Lawrence, Nina,White, Karen L.,Charman, Susan A.,Waterson, David,Witty, Michael J.,Wittlin, Sergio,Botha, Mari?tte E.,Nondaba, Sindisiswe H.,Reader, Janette,Birkholtz, Lyn-Marie,Jiménez-Díaz, María Belén,Martínez, María Santos,Ferrer, Santiago,Angulo-Barturen, Inìigo,Meister, Stephan,Antonova-Koch, Yevgeniya,Winzeler, Elizabeth A.,Street, Leslie J.,Chibale, Kelly

, p. 9890 - 9905 (2016/11/19)

Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyrazine series led to the identification of highly potent compounds against the blood life-cycle stage of the human malaria parasite Plasmodium falciparum. Several compounds displayed high in vivo efficacy in two different mouse models for malaria, P. berghei-infected mice and P. falciparum-infected NOD-scid IL-2Rnull mice. One of the frontrunners, compound 3, was identified to also have good pharmacokinetics and additionally very potent activity against the liver and gametocyte parasite life-cycle stages.

ANTI -MALARIAL AGENTS

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Page/Page column 43-44, (2013/08/28)

The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

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