1450724-26-1

Basic information

• Product Name: C₁₉H₂₁N₃O₇S
• CAS NO: 1450724-26-1
• Molecular Weight: 435.458
• Mol File: 1450724-26-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₁N₃O₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₁N₃O₇S(1450724-26-1)
• EPA Substance Registry System: C₁₉H₂₁N₃O₇S(1450724-26-1)

Safety Data

• Hazardous Substances Data: 1450724-26-1(Hazardous Substances Data)

Upstream product

• 49584-26-1 p-cyanobenzenesulfonyl chloride 
• 62414-68-0 (3R)-piperidin-3-ol 
• 1450723-75-7 C₁₂H₁₄N₂O₃S 
• 1450723-69-9 C₁₂H₁₈N₂O₃S 
• 7693-46-1 4-Nitrophenyl chloroformate 

Downstream Products

• 1450723-46-2 N-[[4-[[(3R)-3-hydroxy-1-piperidyl]sulfonyl]phenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 

Relevant articles and documents

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using structure-based design techniques. The new compounds displayed improved aqueous solubilities, determined using a high-throughput solubility assessment, relative to previously disclosed urea and amide-containing NAMPT inhibitors. An optimized 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived compound exhibited potent anti-NAMPT activity (18; BC NAMPT IC50 = 11 nM; PC-3 antiproliferative IC50 = 36 nM), satisfactory mouse PK properties, and was efficacious in a PC-3 mouse xenograft model. The crystal structure of another optimized compound (29; NAMPT IC50 = 10 nM; A2780 antiproliferative IC50 = 7 nM) in complex with the NAMPT protein was also determined.