1450742-88-7

Basic information

• Product Name: ethyl 7-(4-fluorophenyl)-4-oxo-4H-thieno[3,4-c]pyran-6-carboxylate
• Synonyms: ethyl 7-(4-fluorophenyl)-4-oxo-4H-thieno[3,4-c]pyran-6-carboxylate
• CAS NO: 1450742-88-7
• Molecular Weight: 318.325
• Mol File: 1450742-88-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 7-(4-fluorophenyl)-4-oxo-4H-thieno[3,4-c]pyran-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 7-(4-fluorophenyl)-4-oxo-4H-thieno[3,4-c]pyran-6-carboxylate(1450742-88-7)
• EPA Substance Registry System: ethyl 7-(4-fluorophenyl)-4-oxo-4H-thieno[3,4-c]pyran-6-carboxylate(1450742-88-7)

Safety Data

• Hazardous Substances Data: 1450742-88-7(Hazardous Substances Data)

Upstream product

• 17507-56-1 ethyl 2-diazo-2-(diethoxyphosphoryl)acetate 
• 168542-28-7 4-(4-fluorobenzoyl)thiophene-3-carboxylic acid 

Downstream Products

• 1450742-94-5 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylic acid 
• 1450742-98-9 5-(3-(dimethylamino)propyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylic acid 
• 1450742-91-2 10-(4-fluorophenyl)-3,4-dihydro-1H,6H-thieno[3',4':4,5]pyrido[2,1-c][1,4]oxazine-1,6-dione 
• 1450742-93-4 N-(3,4-dichlorobenzyl)-7-(4-fluorophenyl)-5-(2-hydroxyethyl)-N-methyl-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide 
• 1450742-92-3 ethyl 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate 
• 1450742-95-6 N-(3,4-dichlorobenzyl)-5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-N-methyl-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide 
• 1450742-97-8 ethyl 5-(3-(dimethylamino)propyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate 
• 1450742-99-0 N-(3,4-dichlorobenzyl)-5-(3-(dimethylamino)propyl)-7-(4-fluorophenyl)-N-methyl-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide 
• 1450742-96-7 ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate 
• 1450742-89-8 ethyl 3-(4-fluorophenyl)-2-hydroxy-3-(4-((2-hydroxyethyl)carbamoyl)-3-thienyl)acrylate 
• 1450742-90-1 ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate 

Relevant articles and documents

Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map

Centromere-associated protein-E (CENP-E), a mitotic kinesin that plays an important role in mitotic progression, is an attractive target for cancer therapeutic drugs. For the purpose of developing novel CENP-E inhibitors as cancer therapeutics, we investigated a fused bicyclic compound identified by high throughput screening, 4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide 1a. Based on this scaffold, we designed inhibitors for efficient binding at the L5 site in CENP-E utilizing homology modeling as well as electrostatic potential map (EPM) analysis to enhance CENP-E inhibitory activity. This resulted in a new lead, 5-bromoimidazo[1,2-a]pyridine 7, which showed potent CENP-E enzyme inhibition (IC50: 50 nM) and cellular activity with accumulation of phosphorylated histone H3 in HeLa cells. Our homology model and EPM analysis proved to be useful tools for the rational design of CENP-E inhibitors.