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1450742-92-3

ethyl 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1450742-92-3 Structure

  • Basic information

    1. Product Name: ethyl 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate
    2. Synonyms: ethyl 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate
    3. CAS NO:1450742-92-3
    4. Molecular Formula:
    5. Molecular Weight: 388.463
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1450742-92-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate(1450742-92-3)
    11. EPA Substance Registry System: ethyl 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate(1450742-92-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1450742-92-3(Hazardous Substances Data)

1450742-92-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1450742-92-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,0,7,4 and 2 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1450742-92:
(9*1)+(8*4)+(7*5)+(6*0)+(5*7)+(4*4)+(3*2)+(2*9)+(1*2)=153
153 % 10 = 3
So 1450742-92-3 is a valid CAS Registry Number.

1450742-92-3Relevant articles and documents

Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map

Hirayama, Takaharu,Okaniwa, Masanori,Imada, Takashi,Ohashi, Akihiro,Ohori, Momoko,Iwai, Kenichi,Mori, Kouji,Kawamoto, Tomohiro,Yokota, Akihiro,Tanaka, Toshimasa,Ishikawa, Tomoyasu

, p. 5488 - 5502 (2013/09/02)

Centromere-associated protein-E (CENP-E), a mitotic kinesin that plays an important role in mitotic progression, is an attractive target for cancer therapeutic drugs. For the purpose of developing novel CENP-E inhibitors as cancer therapeutics, we investigated a fused bicyclic compound identified by high throughput screening, 4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide 1a. Based on this scaffold, we designed inhibitors for efficient binding at the L5 site in CENP-E utilizing homology modeling as well as electrostatic potential map (EPM) analysis to enhance CENP-E inhibitory activity. This resulted in a new lead, 5-bromoimidazo[1,2-a]pyridine 7, which showed potent CENP-E enzyme inhibition (IC50: 50 nM) and cellular activity with accumulation of phosphorylated histone H3 in HeLa cells. Our homology model and EPM analysis proved to be useful tools for the rational design of CENP-E inhibitors.

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