1450758-70-9

Upstream product

• 1450758-68-5 benzyl 4-[(1R,2S)-2-(2-oxoethyl)cyclopropyl]piperidine-1-carboxylate 
• 1443739-40-9 tert-butyl (2-aminopyrimidin-5-yl)acetate 
• 1192063-81-2 tert-butyl 4-[(1Z,4R)-5-(benzyloxy)-4-hydroxypent-1-en-1-yl]piperidine-1-carboxylate 
• 287192-97-6 4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1192063-78-7 tert-butyl 4-[(4R)-5-(benzyloxy)-4-hydroxypent-1-yn-1-yl]piperidine-1-carboxylate 
• 1402554-67-9 benzyl 4-[(1R,2S)-2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate 

Downstream Products

• 1450758-71-0 benzyl 4-{(1S,2S)-2-[2-({5-[2-(azetidin-1-yl)-2-oxoethyl]pyrimidin-2-yl}amino)ethyl]cyclopropyl}piperidine-1-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS

Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.