1450760-08-3

Basic information

• Product Name: N-[4-([4-(tert-butylbenzyl)amino(hydroxyimino)methyl]aminomethyl)-2-fluorophenyl]methane sulfonamide
• CAS NO: 1450760-08-3
• Molecular Weight: 422.524
• Mol File: 1450760-08-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[4-([4-(tert-butylbenzyl)amino(hydroxyimino)methyl]aminomethyl)-2-fluorophenyl]methane sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-([4-(tert-butylbenzyl)amino(hydroxyimino)methyl]aminomethyl)-2-fluorophenyl]methane sulfonamide(1450760-08-3)
• EPA Substance Registry System: N-[4-([4-(tert-butylbenzyl)amino(hydroxyimino)methyl]aminomethyl)-2-fluorophenyl]methane sulfonamide(1450760-08-3)

Safety Data

• Hazardous Substances Data: 1450760-08-3(Hazardous Substances Data)

Upstream product

• 401907-26-4 1-(4-t-butylbenzyl)-3-(3-fluoro-4-methanesulfonylaminobenzyl)thiourea 

Relevant articles and documents

Design, synthesis and biological evaluation of B-region modified diarylalkyl amide analogues as novel TRPV1 antagonists

Design, synthesis and biological evaluation of B-region, known to be a dipolar interacting pharmacophore, modified diarylalkyl amide analogues for novel TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) antagonists was described. A variety of moieties including guanidines, heterocyclic rings, cinnamides, and α-substituted acetamides were introduced at the B-region. TRPV1 antagonistic activities of these analogues were evaluated by 45Ca2+ uptake assay in rat DRG neuron. In particular, α,α-difluoroamide 53 exhibited 3-fold more potent TRPV1 antagonistic activity (IC50 = 0.058 μM) than the parent amide analogue 6.