145080-95-1

Basic information

• Product Name: (S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER
• Synonyms: DIETHYL (S)-(-)-2-ISOCYANATOGLUTARATE;DIETHYL (S)-(-)-2-ISOCYANATOPENTANEDIOATE;(S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER;(S)-(-)-2-ISOCYANATOPENTANEDIOIC ACID DIETHYL ESTER;(S)-(-)-2-Isocynatoglutaric acid diethyl ester;Isocynatoglutaricaciddiethylester;(S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER 97+%;Isocynatoglutaricaciddiethyl
• CAS NO: 145080-95-1
• Molecular Formula: C₁₀H₁₅NO₅
• Molecular Weight: 229.23
• Product Categories: Chiral Building Blocks;Isocyanates (Chiral);Synthetic Organic Chemistry
• Mol File: 145080-95-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 151 °C / 10mmHg
• Flash Point: 113.998 °C
• Appearance: /
• Density: 1,13 g/cm3
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: -43.5 ° (C=neat)
• Storage Temp.: Refrigerator
• CAS DataBase Reference: (S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER(145080-95-1)
• EPA Substance Registry System: (S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER(145080-95-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 145080-95-1(Hazardous Substances Data)

Usage

General Description

(S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER is a chemical compound characterized by the presence of an isocyanate functional group. It is a diethyl ester derivative of isocyanatoglutaric acid, and it is commonly used as an intermediate in the synthesis of various organic compounds. This chemical is often utilized in the production of polymers, adhesives, and coatings, as well as in the manufacturing of pharmaceuticals and agrochemicals. It possesses valuable reactivity and properties that make it useful in a variety of industrial applications. Additionally, (S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER has the potential for further research and development in the field of organic chemistry due to its unique structure and functional groups.

InChI:InChI=1/C10H15NO5/c1-3-15-9(13)6-5-8(11-7-12)10(14)16-4-2/h8H,3-6H2,1-2H3/t8-/m0/s1

Upstream product

• 1118-89-4 diethyl-L-glutamate hydrochloride 
• 503-38-8 trichloromethyl chloroformate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 75-44-5 phosgene 

Downstream Products

• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 564482-88-8 [121I]-DCIT 
• 42558-84-9 N,N-Bis-(2-chlor-aethyl)-carbamyl-L-glutaminsaeure-diaethylester 

Relevant articles and documents

Synthesis process of Raltitrexed key intermediate

The invention relates to the technical field of medicine preparation, in particular to a synthesis process of a Raltitrexed key intermediate. According to the synthesis process of the Raltitrexed keyintermediate, forming an active intermediate (isocyanate) through glutamate diethyl ester, the active intermediate and N-methyl-(2-thienyl) tert-butyl carbamate are directly reacted, and a target product N-[5-[N-(t-butyloxycarboryl)-N-methyl amino]-2-thenoyl]-L-glutamate diethyl ester is prepared by two steps. The synthesis process avoids difficulties of potential risks of part of racemization ofa chiral center caused by amidation reaction, low yield, complicated operation and purification and the like. The synthesis process of the Raltitrexed key intermediate is simple to operate, short in line, environmentally friendly and high in yield.