1450824-73-3

Basic information

• Product Name: 4-(2-(3-chlorophenylformyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one
• Synonyms: 4-(2-(3-chlorophenylformyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one
• CAS NO: 1450824-73-3
• Molecular Weight: 393.223
• Mol File: 1450824-73-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-(3-chlorophenylformyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(3-chlorophenylformyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one(1450824-73-3)
• EPA Substance Registry System: 4-(2-(3-chlorophenylformyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one(1450824-73-3)

Safety Data

• Hazardous Substances Data: 1450824-73-3(Hazardous Substances Data)

Upstream product

• 100074-30-4 phenylacetic acid 
• 1878-66-6 4-chlorophenylacetic Acid 
• 1320275-79-3 C₁₂H₁₀BrClO₃ 
• 17264-88-9 sodium 3-chlorobenzoate 

Relevant articles and documents

3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: Synthesis, molecular docking and antibacterial evaluation

Thirty-eight 3-aryl-4-acyloxyethoxyfuran-2(5H)-ones were designed, prepared and tested for antibacterial activities. Some of them showed significant antibacterial activity against Gram-positive organism, Gram-negative organism and fungus. Out of these compounds, 4-(2-(3-chlorophenylformyloxy)ethoxy)-3-(4- chlorophenyl)furan-2(5H)-one (d40) showed the widest spectrum of activity with MIC50 of 2.0 μg/mL against Staphylococcus aureus, 4.3 μg/mL against Escherichia coli, 1.5 μg/mL against Pseudomonas aeruginosa and 1.2 μg/mL against Candida albicans. Our data disclosed that MIC50 values against whole cell bacteria are positive correlation with MIC 50 values against tyrosyl-tRNA synthetase. Meanwhile, molecular docking of d40 into S. aureus tyrosyl-tRNA synthetase active site was also performed, and the inhibitor tightly fitting the active site might be an important reason why it has high antimicrobial activity.