1450894-33-3Relevant academic research and scientific papers
Cooperative Catalysis for the Highly Diastereo- and Enantioselective [4+3]-Cycloannulation of ortho-Quinone Methides and Carbonyl Ylides
Loui, Henning Jakob,Schneider, Christoph,Suneja, Arun
, p. 5536 - 5540 (2020)
We describe herein a highly diastereo- and enantioselective [4+3]-cycloannulation of ortho-quinone methides and carbonyl ylides to furnish functionalized oxa-bridged dibenzooxacines with excellent yields and stereoselectivity in a single synthetic step. The combination of rhodium and chiral phosphoric acid catalysis working in concert to generate both transient intermediates in situ provides direct access to complex bicyclic products with two quaternary and one tertiary stereogenic centers. The products may be further functionalized into valuable and enantiomerically highly enriched building blocks.
Acylalkylation of Arynes Generated from o-Iodoaryl Triflates with Hydrosilanes and Cesium Fluoride
Minoshima, Mai,Uchida, Keisuke,Nakamura, Yu,Hosoya, Takamitsu,Yoshida, Suguru
supporting information, p. 1868 - 1873 (2021/03/08)
An efficient method to generate aryne intermediates from o-iodoaryl triflates triggered by triethylsilane and cesium fluoride is disclosed. This method realized the acylalkylation of arynes using easily available o-iodoaryl triflate-type precursors, which was difficult when using conventional nucleophilic activators. A wide range of (hetero)arenes including various fused benzothiazoles were successfully synthesized from o-iodoaryl triflates by virtue of their good accessibility and divergent transformations of aryne intermediates.
A novel and convenient strategy for the synthesis of phthalazines from an aryne precursor
Bel Abed, Hassen,Bande, Omprakash,Mammoliti, Oscar,Van Lommen, Guy,Herdewijn, Piet
supporting information, p. 7056 - 7058 (2013/12/04)
A novel three-step entry toward phthalazine derivatives has been elaborated. A strategy based on a sequential acyl-alkylation/diazo transfer reaction/Diaza-Wittig reaction led to the desired analogues in moderate to good yields from an aryne precursor. Various aryl groups were introduced on the annulated pyridazine, moreover the presence of an ester group allows further modifications.
BIPHENYL INTEGRIN ANTAGONISTS
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Page/Page column 35-36, (2010/11/08)
The following invention is directed to pharmaceutical compounds and compositions of the Formula (I). useful for treating conditions mediated by αVβ3 and/or αVβ5 integrin.
