50439-04-8

Upstream product

• 100-66-3 methoxybenzene 
• 703-59-3 homophthalic anhydride 
• 118-90-1 ortho-methylbenzoic acid 
• 130250-61-2 2-methyl-N-methoxy-N-methylbenzamide 
• 124-38-9 carbon dioxide 
• 41204-59-5 (4-methoxyphenyl)(2-methylphenyl)methanone 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 7446-70-0 aluminium trichloride 
• 38199-92-7 3-(4-methoxyphenyl)-1H-indene 
• 83-33-0 inden-1-one 

Downstream Products

• 64262-34-6 10b-(4-methoxy-phenyl)-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 
• 1450894-33-3 ethyl 2-(2-(4-methoxybenzoyl)phenyl)acetate 
• 10324-03-5 (4-Methoxybenzyl)-2-phenylessigsaeure 
• 77605-67-5 1-(4-methoxy-phenyl)-isochroman-3-one 

Relevant academic research and scientific papers

Light-Driven Carboxylation of o-Alkylphenyl Ketones with CO2

o-Alkylphenyl ketones undergo a C-C bond forming carboxylation reaction with CO2 simply upon irradiation with UV light or even solar light. The reaction presents a clean process exploiting light energy as the driving force for carboxylation of organic molecules with CO2.

BIPHENYL INTEGRIN ANTAGONISTS

The following invention is directed to pharmaceutical compounds and compositions of the Formula (I). useful for treating conditions mediated by αVβ3 and/or αVβ5 integrin.

Reactions of carbonyl compounds in basic solutions. Part 21. The mechanisms of the alkaline hydrolysis of substituted methyl 2-(2-oxopropyl)- and 2-(2-oxo-2-phenylethyl)-benzoates and 2-(2-acetylphenyl)- and 2-(2-benzoylphenyl)-acetates

Rate coefficients have been measured for the alkaline hydrolysis of methyl 2-[2-oxo-2-(3- or 4-substituted phenyl)ethyl]benzoates, 2-[2-(3- or 4-substituted benzoyl)phenyl]acetates,2-(2-oxopropyl) and 2-(1,1-dimethyl-2- oxopropyl)benzoates, 2-(2-acetylphenyl)acetate and 2-(2-acetylphenyl)-2,2- dimethylacetates in 70% (v/v) dioxane-water at 30.0 °C. Those for the six parent esters were also measured at 45.0 and 60.0 °C and the enthalpies and entropies of activation have been evaluated. The relative rates of hydrolysis, activation parameters and substituent effects have been used to demonstrate neighbouring participation by the keto-carbonyl groups in the alkaline hydrolysis of the esters under study. For comparable systems, participation by six-membered ring intermediates appears somewhat less advantageous than five-membered.

2-(Arylmethyl)arylacetic Acids as Potential Antiinflammatory Agents

The title compounds 2 have been synthesized and tested for antiinflammatory activity.The synthetic method, consisting of the chemical sequence 3-aryl-1H-indenes (4) 2-(aroyl)arylacetic acids (5) 2, appears to be of value because of its simplicity