1450982-18-9

Upstream product

• 4989-27-9 4-ethyl-5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid 
• 4949-58-0 2-(ethyloxycarbonyl)-3-ethyl-4-methylpyrrole 
• 100780-37-8 2-nitro-3-acetoxy-pentane 
• 20575-40-0 2-nitropentan-3-ol 
• 1450982-09-8 3‐ethyl‐4‐methyl‐1H,1′H‐[2,2′‐bipyrrole]‐5‐carbaldehyde 
• 1450982-15-6 C₁₈H₂₄FN 
• 19711-77-4 5-bromo-4-ethyl-3-methyl-pyrrole-2-carboxaldehyde 

Relevant academic research and scientific papers

Synthesis of 2,2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines

Facile, versatile, and cost-effective synthetic routes for the preparation of a range of new 3-alkyl-, 4-alkyl-, 3,4-dialkyl-, and 3-halo-4-alkyl-2, 2′-bipyrrole-5-carboxaldehydes have been developed. These 2,2′-bipyrrole-5-carboxaldehydes offer interesting potential as building blocks for making bioactive natural and unnatural products, as demonstrated by the synthesis of B-ring functionalized prodiginines (PGs) and tambjamines.

Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials

Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity and structure-activity relationsh