1450994-72-5Relevant academic research and scientific papers
BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE
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, (2021/04/01)
The disclosure provides BRD9 bifunctional compounds of Formula (A) or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, to their preparation, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases and disorders mediated by a bromodomain-containing protein, such as bromodoma in-containing protein 9 (BRD9)
Total synthesis of eryvarin H and its derivatives and their biological activity as ERRγ inverse agonist
Koo, Ja Young,Oh, Sangmi,Cho, Seung-Rye,Koh, Minseob,Oh, Won-Keun,Choi, Hueng-Sik,Park, Seung Bum
, p. 5782 - 5786 (2013/09/12)
Total synthesis of eryvarin H and a biological investigation of its analogues as a potential inverse agonist of ERRγ are described here. Among the 13 analogues prepared by the modular synthetic route, eryvarin H and compound 12 showed meaningful ERRγ inverse agonistic activities along with moderate selectivity over ERα and other nuclear receptors in the cell-based reporter gene assay.
