1451061-11-2Relevant academic research and scientific papers
Copper-catalyzed selective oxidative acylation of secondary anilines with ethyl glyoxalate: Domino synthesis of indoline-2,3-diones
Liu, Tao,Yang, Haijun,Jiang, Yuyang,Fu, Hua
, p. 1169 - 1176 (2013)
A novel, easy and useful copper-catalyzed selective acylation of secondary anilines with ethyl glyoxalate has been developed, and the corresponding indoline-2,3-dione derivatives were prepared. The procedure comprises the sequential intermolecular copper-catalyzed selective oxidative ortho-site aromatic acylation of the NH group in secondary anilines and intramolecular nucleophilic attack of the NH group to the ester. The inexpensive, easy and efficient method should provide a new strategy for synthesis of dicarbonyl compounds. Copyright
