1451076-35-9Relevant academic research and scientific papers
Synthesis and biological evaluation of tetrahydropyridinepyrazoles ('PFPs') as inhibitors of STAT3 phosphorylation
Revanna,Srinivasa,Li, Feng,Siveen, Kodappully Sivaraman,Dai, Xiaoyun,Swamy, Shivananju Nanjunda,Bhadregowda,Sethi, Gautam,Mantelingu,Bender, Andreas,Ks, Rangappa
, p. 32 - 40 (2014/01/06)
The transcription factor STAT3 is constitutively overexpressed in many human tumors and hence represents a putative target for anticancer drug design. In this work, we describe the synthesis and biological evaluation of a novel chemotype, pyridine-fused p
Convenient synthesis of novel N-(5-allyl-7,7-difluoro)-4,5,6,7-tetrahydro- 2H-indazol-3-yl)-carboxymides
Revanna, Chigalli N.,Raghavendra, Goravanahalli M.,Nandeesh, Kebbahalli N.,Bhadregowda, Doddamedur G.,Rangappa, Kanchugarakoppal S.,Mantelingu, Kempegowda
supporting information, p. 5224 - 5226 (2013/09/02)
5-Allyl-7,7-difluoro-2-(2,4-difluorophenyl)-6-(4-methoxyphenyl)-4,5,6, 7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-amine represents a fluorinated heterocyclic scaffold, potentially attractive. It was synthesized via Michael addition, Mannich reaction of the
