1451076-35-9Relevant articles and documents
Synthesis and biological evaluation of tetrahydropyridinepyrazoles ('PFPs') as inhibitors of STAT3 phosphorylation
Revanna,Srinivasa,Li, Feng,Siveen, Kodappully Sivaraman,Dai, Xiaoyun,Swamy, Shivananju Nanjunda,Bhadregowda,Sethi, Gautam,Mantelingu,Bender, Andreas,Ks, Rangappa
, p. 32 - 40 (2014/01/06)
The transcription factor STAT3 is constitutively overexpressed in many human tumors and hence represents a putative target for anticancer drug design. In this work, we describe the synthesis and biological evaluation of a novel chemotype, pyridine-fused p