1451079-89-2

Upstream product

• 1451079-81-4 (2S)-5-allyl-4-tert-butyldimethylsilyloxy-2-trityloxymethyl-3,6-dihydro-2H-pyran 
• 1451079-79-0 (2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methanol 
• 1451079-77-8 (-)-(2S)-ethyl 5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-carboxylate 
• 1451079-76-7 2-tert-butyldimethylsilyloxy-3-methylenehexa-1,5-diene 
• 52358-87-9 3-methylenehex-5-en-2-one 

Downstream Products

• 1451079-96-1 (2S,5R)-5-hydroxy-5-(2-oxopropyl)-2-(trityloxymethyl)-tetrahydropyran-4-one 

Relevant academic research and scientific papers

Asymmetric synthesis of (-)-bissetone via a highly enantioselective hetero-Diels-Alder reaction

We demonstrate a new approach for the asymmetric synthesis of bissetone. The key reaction is the highly enantioselective hetero-Diels-Alder cycloaddition of triene 3 with ethyl glyoxylate catalyzed by readily available BINOL-Ti complexes. The HDA cycloadduct 4 was then transformed in five steps into O-protected bissetone (8) and its C5-epimer in good yield.