52358-87-9

Upstream product

• 3508-78-9 3-allyl-2,4-pentanedione 
• 50-00-0 formaldehyd 

Downstream Products

• 111718-49-1 ((2S,5R)-5-hydroxy-5-(2-oxopropyl)-4-oxo-tetrahydro-2H-pyran-2-yl)methyl benzoate 
• 111718-47-9 ((2S,5S)-5-hydroxy-5-(2-oxopropyl)-4-oxo-tetrahydro-2H-pyran-2-yl)methyl benzoate 
• 1451079-96-1 (2S,5R)-5-hydroxy-5-(2-oxopropyl)-2-(trityloxymethyl)-tetrahydropyran-4-one 
• 1451079-85-8 (2S,5S)-5-hydroxy-5-(2-oxopropyl)-2-(trityloxymethyl)-tetrahydropyran-4-one 
• 1451079-93-8 ((2S,5R)-5-allyl-5-hydroxy-4-oxo-tetrahydro-2H-pyran-2-yl)methyl benzoate 
• 1451079-91-6 ((2S,5S)-5-allyl-5-hydroxy-4-oxo-tetrahydro-2H-pyran-2-yl)methyl benzoate 
• 1451079-89-2 (2S,5R)-5-allyl-5-hydroxy-2-(trityloxymethyl)-tetrahydropyran-4-one 
• 1451079-83-6 (2S,5S)-5-allyl-5-hydroxy-2-(trityloxymethyl)-tetrahydropyran-4-one 
• 1451079-87-0 (2S)-(5-allyl-4-tert-butyldimethylsilyloxy-3,6-dihydro-2H-pyran-2-yl)methyl benzoate 
• 1451079-81-4 (2S)-5-allyl-4-tert-butyldimethylsilyloxy-2-trityloxymethyl-3,6-dihydro-2H-pyran 

Relevant academic research and scientific papers

The bidirectional total synthesis of sampsonione P and hyperibone i

Make it simple: The separation of framework-decorating from framework-constructing steps facilitated the selective introduction of one prenyl group next to allyl groups. The selective epoxidation of the more electron-rich prenyl group led to the efficient formation of the tetrahydrofuran moiety in the title compounds. Spectroscopic analysis of hyperiboneI and comparison with literature data led to a revision of the original structure. Copyright

Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands

In the search of new probes for in vivo brain imaging of vesicular monoamine transporter type 2 (VMAT2), we have developed an efficient synthesis of a novel series of 3-alkyl-dihydrotetrabenazine (DTBZ) derivatives. The affinity of VMAT2 was evaluated by an in vitro inhibitory binding assay using [125I]-iodovinyl-TBZ or [18F](+)-FP-DTBZ as radioligands in rat striatal tissue homogenates. New DTBZ derivatives exhibited moderate to good binding affinity to VMAT2. Among these new ligands, compound 4b showed the best affinity for VMAT2 (Ki = 5.98 nM) and may be a useful lead compound for future structure-activity studies.