1451144-18-5Relevant articles and documents
Enantioselective total synthesis of (-)-limaspermidine and formal synthesis of (-)-1-acetylaspidoalbidine
Zhang, Shao-Xiong,Shen, Xiao-Lei,Li, Ze-Qian,Zou, Li-Wei,Wang, Feng-Qun,Zhang, Hong-Bin,Shao, Zhi-Hui
, p. 11444 - 11449 (2013/12/04)
Evolution of the synthetic strategy that culminated in the first asymmetric total synthesis of the Aspidosperma alkaloid limaspermidine is described. The successful enantioselective route to (-)-limaspermidine proceeds in 10 steps and with the isolation of only six intermediates using a Pd-catalyzed enantioselective decarboxylative allylation we have recently developed. This first enantioselective synthesis of (-)-limaspermidine establishes unambiguously its absolute configuration and allows the first asymmetric formal total synthesis of the Aspidoalbine alkaloid (-)-1-acetylaspidoalbidine.
Enantioselective palladium-catalyzed decarboxylative allylation of carbazolones: Total synthesis of (-)-aspidospermidine and (+)-kopsihainanineA
Li, Zeqian,Zhang, Shaoxiong,Wu, Shoutao,Shen, Xiaolei,Zou, Liwei,Wang, Fengqun,Li, Xiang,Peng, Fangzhi,Zhang, Hongbin,Shao, Zhihui
supporting information, p. 4117 - 4121 (2013/05/08)
Functionalized chiral carbazolones with α-quaternary carbon centers are formed through the ligand-controlled Pd-catalyzed enantioselective decarboxylative allylic alkylation of carbazolones (see scheme). This catalytic asymmetric reaction was employed as the key step in the total synthesis of aspidospermidine and (+)-kopsihainanineA. Copyright
