1451153-07-3Relevant academic research and scientific papers
Synthesis of polyfluoroalkyl cyclobutenes from 3-aza-1,5-enynes via an aza-Claisen rearrangement/cyclization cascade
Xin, Xiaoyi,Wang, Dongping,Wu, Fan,Wang, Chunxiang,Wang, Haolong,Li, Xincheng,Wan, Boshun
, p. 4512 - 4515 (2013)
A facile synthetic route to access polyfluoroalkyl functionalized cyclobutenes bearing an exo cyclic double bond from 3-aza-1,5-enynes is reported. The reaction proceeds via a thermal aza-Claisen rearrangement to give an allene-imine intermediate; subsequent cyclization affords the cyclobutene core. The kinetics of the transformation of starting material and the intermediate was studied by 1H NMR spectroscopy, where a consecutive reaction was revealed.
