1451195-24-6

Basic information

• Product Name: (R)-3-methyl-4-(2-nitro-1-(thiophen-2-yl)ethyl)-1-phenyl-1H-pyrazol-5-ol
• Synonyms: (R)-3-methyl-4-(2-nitro-1-(thiophen-2-yl)ethyl)-1-phenyl-1H-pyrazol-5-ol
• CAS NO: 1451195-24-6
• Molecular Weight: 329.379
• Mol File: 1451195-24-6.mol

Chemical Properties

• CAS DataBase Reference: (R)-3-methyl-4-(2-nitro-1-(thiophen-2-yl)ethyl)-1-phenyl-1H-pyrazol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-methyl-4-(2-nitro-1-(thiophen-2-yl)ethyl)-1-phenyl-1H-pyrazol-5-ol(1451195-24-6)
• EPA Substance Registry System: (R)-3-methyl-4-(2-nitro-1-(thiophen-2-yl)ethyl)-1-phenyl-1H-pyrazol-5-ol(1451195-24-6)

Safety Data

• Hazardous Substances Data: 1451195-24-6(Hazardous Substances Data)

Upstream product

• 874-84-0 2-(2-nitroethenyl)thiophene 
• 89-25-8 edaravone 

Relevant articles and documents

Highly enantioselective Michael addition of pyrazolin-5-ones to nitroolefins catalyzed by cinchona alkaloid derived 4-methylbenzoylthioureas

Cinchona alkaloid-derived 4-methyl/nitro benzoylthioureas were synthesized, which smoothly catalyzed the asymmetric Michael addition of pyrazolin-5-ones to nitroolefins. The results showed that electronic effects of substituents in the benzene ring of benzoylthioureas have subtle influences on their catalytic abilities and electron donating methyl group is favored than electron withdrawing nitro group. Preliminary Hartree-Fock calculations revealed that in the catalytic cycle, hydrogen bond energies of the complex formed with 4-methylbenzoylthioureas are about 0.19 to 1.56?kcal/mol higher than with the corresponding 4-nitrobenzoylthioureas. 4-Methylbenzoylthioureas were identified as the most effective catalysts that promoted asymmetric Michael addition of pyrazolin-5-ones to nitroolefins to give the S- or R-products with high enantioselectivities.

Chiral squaramide catalyzed synthesis of C4 substituted chiral pyrazol-3-ol derivatives via a facile asymmetric Michael addition of 3-methyl-2-pyrazolin-5-one to β-nitrostyrenes

Asymmetric Michael addition of 3-methyl-2-pyrazolin-5-one to β-nitrostyrenes, catalyzed by a series of chiral squaramide bifunctional catalysts derived from cinchona alkaloids, yielded chiral pyrazol-3-ol derivatives. These pyrazol-3-ol derivatives were o

Squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to nitroalkenes

An efficient chiral squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to nitroalkenes has been developed. This reaction afforded the chiral pyrazol-3-ol derivatives in high to excellent yields (up to >99%) with high enantioselecti