145131-17-5 Usage
Uses
Used in Pharmaceutical Industry:
1-(2,4-difluorophenyl)-3-[1-(1-methyl-1H-indol-3-yl)cyclopentyl]methylurea is used as a potential therapeutic agent for the development of novel drugs. Its unique chemical structure suggests that it may interact with various biological targets, potentially leading to the creation of new medications with improved efficacy and reduced side effects.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(2,4-difluorophenyl)-3-[1-(1-methyl-1H-indol-3-yl)cyclopentyl]methylurea serves as a valuable compound for studying its interactions with different biological molecules. Understanding these interactions can provide insights into its potential therapeutic uses and help in the design of more effective drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 145131-17-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,1,3 and 1 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 145131-17:
(8*1)+(7*4)+(6*5)+(5*1)+(4*3)+(3*1)+(2*1)+(1*7)=95
95 % 10 = 5
So 145131-17-5 is a valid CAS Registry Number.
145131-17-5Relevant academic research and scientific papers
New indole derivatives as ACAT inhibitors: Synthesis and structure-activity relationships
Bellemin,Decerprit,Festal
, p. 123 - 132 (2007/10/03)
A series of ureas containing the indole group were synthesized and assessed for their ability to inhibit arterial and intestinal ACAT and to lower plasma total cholesterol in a cholesterol-fed rat model. The structural modulations carried out in this series led to compounds which proved to be very active in both the inhibition of aortic ACAT in vitro and the inhibition of rat cholesterol intestinal absorption in vivo. Several compounds from this series exhibit a remarkable hypocholesterolaemic effect with ED25 less than 0.1 mg/kg po.
