145131-62-0 Usage
Classification
Urea derivative
Structure
Contains a phenyl group substituted with two isopropyl groups and a hexyl group attached to a urea moiety through a chiral carbon (2R)
Potential applications
Medicinal chemistry due to its potential biological activities
Biological activities
Interaction with cellular targets or potential as a therapeutic agent
Pharmacological properties
Not explicitly stated, further research needed
Toxicological properties
Not explicitly stated, further research needed
Research status
Further research is needed to fully understand its potential applications and effects
Please note that this list is based on the information provided and may not be exhaustive. Further research and analysis may reveal additional properties and specific content related to 1-[2,6-bis(1-methylethyl)phenyl]-3-[(2R)-2-(1-methyl-1H-indol-3-yl)hexyl]urea.
Check Digit Verification of cas no
The CAS Registry Mumber 145131-62-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,1,3 and 1 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 145131-62:
(8*1)+(7*4)+(6*5)+(5*1)+(4*3)+(3*1)+(2*6)+(1*2)=100
100 % 10 = 0
So 145131-62-0 is a valid CAS Registry Number.
145131-62-0Relevant academic research and scientific papers
New indole derivatives as ACAT inhibitors: Synthesis and structure-activity relationships
Bellemin,Decerprit,Festal
, p. 123 - 132 (2007/10/03)
A series of ureas containing the indole group were synthesized and assessed for their ability to inhibit arterial and intestinal ACAT and to lower plasma total cholesterol in a cholesterol-fed rat model. The structural modulations carried out in this series led to compounds which proved to be very active in both the inhibition of aortic ACAT in vitro and the inhibition of rat cholesterol intestinal absorption in vivo. Several compounds from this series exhibit a remarkable hypocholesterolaemic effect with ED25 less than 0.1 mg/kg po.
