1451371-30-4

Upstream product

• 123-91-1 1,4-dioxane 
• 103-19-5 di(p-tolyl) disulfide 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 106-45-6 para-thiocresol 
• 2564-83-2 2,2,6,6-tetramethyl-piperidine-N-oxyl 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 29627-34-7 4-(phenyldisulfanyl)toluene 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant academic research and scientific papers

Nickel-catalyzed oxidative dehydrogenative coupling of alkane with thiol for C(sp3)-S bond formation

A nickel-catalyzed oxidative dehydrogenative coupling reaction of alkane with thiol for the construction of C(sp3)-S bond has been established, affording more than 50 alkyl thioethers. Notably, pharmaceutical and agrochemicals, such as Provigil, Chlorbenside and Pyridaben, were readily synthesized by this approach. The sterically hindered ligand BC and disulfide which was formed in situ oxidation of thiol, efficiently avoiding nickel-catalyst poisoning. A set of mechanistic experiments disclose both Ni-catalyzed and Ni-free HAA processes.

Efficient C?S Bond Formation by Direct Functionalization of C(sp3)?H Bond Adjacent to Heteroatoms under Metal-Free Conditions

A simple and efficient method for the formation of C?S bond via direct functionalization of C(sp3)?H bond adjacent to heteroatoms was described under metal-free conditions. In this work, stable and easily accessible sodium sulfinates were used as the thiolating agents to afford various aryl thioethers in moderate to excellent yields. Mechanistic explorations show that a radical pathyway is possibly involved during the transformations. (Figure presented.).

Preparation method of alkyl sulfide

The invention relates to a preparation method of alkyl sulfide. The method comprises the following steps: under the protection of nitrogen, sequentially adding transition metal, a nitrogen ligand, a cocatalyst, an oxidant, a solvent, alkane and thiophenol or mercaptan into a reaction tube, carrying out oxidative dehydrogenation coupling reaction at 80-150 DEG C, ending the reaction after 6-48 hours, evaporating the solvent to dryness, and carrying out column chromatography separation to obtain the alkyl sulfide compound. The method is simple in synthesis process, mild in reaction condition, high in yield and easy to industrialize.

Visible-Light-Induced Direct Thiolation at α-C(sp3)-H of Ethers with Disulfides Using Acridine Red as Photocatalyst

A simple and efficient method for the preparation of α-arylthioethers through a visible-light-induced direct thiolation at α-C(sp3)-H of ethers with diaryl disulfides was developed using acridine red as a novel photocatalyst. The reactions occurred at ambient conditions and generated the corresponding products in good to excellent yields, ignoring steric effect of disulfides.

Palladium-catalyzed direct thiolation of ethers with sodium sulfinates

A new method for palladium-catalyzed arylthiolation of ethers with sodium sulfinates is described. The CH bond in various ethers was successfully converted into CS bond to yield the corresponding sulfides in moderate to good yields.

Palladium-catalyzed thiolation of alkanes and ethers with arylsulfonyl hydrazides

A new method for the preparation of alkyl aryl sulfides through direct oxidative thiolation of alkanes or ethers with arylsulfonyl hydrazides using di-tert-butyl peroxide (DTBP) as an oxidant catalyzed by Pd(OAc)2 has been reported. The C-H bonds in various alkanes or ethers were successfully converted into C-S bonds to yield the corresponding sulfides in moderate to good yields. the Partner Organisations 2014.

Metal-free oxidative C(sp3)-H bond thiolation of ethers with disulfides

A novel method for the preparation of alkyl aryl sulfides through direct oxidation thiolation of commercial ethers with diaryl disulfides using di-tert-butyl peroxide (DTBP) as the oxidant without a metal catalyst was established. The C(sp3)-H