1451392-22-5Relevant articles and documents
Preparation method of boracic micromolecule
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Paragraph 0114; 0118-0120, (2018/12/14)
The invention discloses a preparation method of a boracic micromolecule 5-(4-cyanophenoxyl)-1,3-dihydro-1-hydroxy-2,1-benzodioxole. The preparation method includes the steps of (1) subjecting 2-bromine-5-hydroxybenzaldehyde to reduction reaction in solvent with the presence of reducing agents to obtain 2-bromine-5-hydroxybenzyl alcohol; (2) subjecting 2-bromine-5-hydroxybenzyl alcohol and a hydroxyl protection reagent to reaction in solvent with the presence of alkali; (3) subjecting the previous reactant to borate reaction in solvent under an alkaline condition; (4) removing hydroxyl protecting groups from the previous reactant to obtain a benzo[c][1,2]heterocyclopentadiene-1,5(3H)-glycol body; (5) subjecting the previous reactant to reaction in solvent under an alkaline condition to obtain a target object. The preparation method has the advantages of low cost of technological raw materials, easiness in obtaining of the technological raw materials, remarkably improved reaction yield,simplicity in operation, low cost and applicability to industrial production.
