1451409-00-9

Basic information

• Product Name: 5-(1-(2,6-dimethylphenyl)-1H-tetrazol-5-yl)-4-(4-fluoro-benzyl)-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-one
• CAS NO: 1451409-00-9
• Molecular Weight: 443.48
• Mol File: 1451409-00-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(1-(2,6-dimethylphenyl)-1H-tetrazol-5-yl)-4-(4-fluoro-benzyl)-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1-(2,6-dimethylphenyl)-1H-tetrazol-5-yl)-4-(4-fluoro-benzyl)-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-one(1451409-00-9)
• EPA Substance Registry System: 5-(1-(2,6-dimethylphenyl)-1H-tetrazol-5-yl)-4-(4-fluoro-benzyl)-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-one(1451409-00-9)

Safety Data

• Hazardous Substances Data: 1451409-00-9(Hazardous Substances Data)

Upstream product

• 40359-34-0 methyl o-formylphenoxyacetate 
• 6280-80-4 2-Formylphenoxyacetic acid 

Relevant articles and documents

Bifunctional building blocks in the Ugi-azide condensation reaction: A general strategy toward exploration of new molecular diversity

1,5-Disubstituted tetrazoles are an important drug-like scaffold known for their ability to mimic the cis-amide bond conformation. The scaffold is readily accessible via substitution of the carboxylic acid component of the Ugi multi-component reaction (MCR) with TMSN3 in what is herein denoted the Ugi-azide reaction. This full paper presents a concise, novel, general strategy to access a plethora of new heterocylic scaffolds utilizing tethered aldo/keto-acids/esters in the Ugi-azide reaction followed by a ring closing event that generates novel highly complex bis-heterocyclic lactam-tetrazoles. The Royal Society of Chemistry.