145144-78-1

Basic information

• Product Name: ethyl 5-phenyl-2-(2'-thiopyridyl)-2-trifluoroacetoxy pentanoate
• Synonyms: ethyl 5-phenyl-2-(2'-thiopyridyl)-2-trifluoroacetoxy pentanoate
• CAS NO: 145144-78-1
• Molecular Weight: 427.444
• Mol File: 145144-78-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 5-phenyl-2-(2'-thiopyridyl)-2-trifluoroacetoxy pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-phenyl-2-(2'-thiopyridyl)-2-trifluoroacetoxy pentanoate(145144-78-1)
• EPA Substance Registry System: ethyl 5-phenyl-2-(2'-thiopyridyl)-2-trifluoroacetoxy pentanoate(145144-78-1)

Safety Data

• Hazardous Substances Data: 145144-78-1(Hazardous Substances Data)

Upstream product

• 368-28-5 ethyl α-(trifluoroacetoxy)acrylate 
• 114050-31-6 3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester 
• 140-88-5 ethyl acrylate 
• 145144-77-0 ethyl 5-phenyl-2-(2'-thiopyridyl)pentanoate 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 163975-28-8 ethyl 5-phenyl-2-(pyridine-2'-sulfinyl)pentanoate 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 88768-11-0 2-oxo-5-phenylpentanoic acid 
• 153558-53-3 5-phenyl-1,2-pentanediol 

Relevant articles and documents

The invention of radical reactions. Part XXXIV. Homologation of carboxylic acids to α-keto carboxylic acids by Barton-ester based radical chain chemistry

Carboxylic acids can be transformed into the homologous α-keto acids by Barton-ester based radical chemistry. The method was especially successful when ethyl α-trifluoroacetoxy acrylate was used as a radical trap.

Two Carbon Homologation of Carboxylic Acids via Carbon Radicals Generated from the Acyl Derivatives of N-Hydroxy-2-thiopyridone: Synthesis of Cn+2 α-Keto-acids from Cn Acids. (The 'Three carbon' Problem).

Reaction of olefins containing a three carbon atom chain with carbon radicals generated from carboxylic acids furnishes adducts that are precursors of the corresponding two carbon atom longer α-keto-acids.These keto-acids are furnished in high overall yield.