1451475-78-7Relevant academic research and scientific papers
Dimerization of conserved ascaroside building blocks generates species-specific male attractants in: Caenorhabditis nematodes
Bandi, Siva,Dolke, Franziska,Dong, Chuanfu,Paetz, Christian,Von Reu?, Stephan H.
, p. 5253 - 5263 (2020/07/23)
Comparative ascaroside profiling of Caenorhabditis nematodes using HPLC-ESI-(-)-MS/MS precursor ion scanning revealed a class of highly species-specific ascaroside dimers. Their 2- and 4-isomeric, homo- and heterodimeric structures were identified using a combination of HPLC-ESI-(+)-HR-MS/MS spectrometry and high-resolution dqf-COSY NMR spectroscopy. Structure assignments were confirmed by total synthesis of representative examples. Functional characterization using holding assays indicated that males of Caenorhabditis remanei and Caenorhabditis nigoni are exclusively retained by their conspecific ascaroside dimers, demonstrating that dimerization of conserved monomeric building blocks represents a yet undescribed mechanism that generates species-specific signaling molecules in the Caenorhabditis genus. This journal is
Ascaroside activity in Caenorhabditis elegans is highly dependent on chemical structure
Hollister, Kyle A.,Conner, Elizabeth S.,Zhang, Xinxing,Spell, Mark,Bernard, Gary M.,Patel, Pratik,De Carvalho, Ana Carolina G.V.,Butcher, Rebecca A.,Ragains, Justin R.
, p. 5754 - 5769 (2013/09/12)
The nematode Caenorhabditis elegans secretes ascarosides, structurally diverse derivatives of the 3,6-dideoxysugar ascarylose, and uses them in chemical communication. At high population densities, specific ascarosides, which are together known as the dau
