145162-70-5Relevant academic research and scientific papers
HETEROARYL SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF
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Page/Page column 315, (2022/02/15)
The present disclosure provides a compound of Formula (I): (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx and X1 are as defined herein, and methods of making and using same.
PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS
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Page 137, (2008/06/13)
Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
Synthesis of 2-Alkylpyrazole-1-oxides: A Facile Access to 1-Alkyl-5-halopyrazoles
Eskildsen, Joergen,Vedsoe, Per,Begtrup, Mikael
, p. 1053 - 1056 (2007/10/03)
Selective N-alkylation of 1-hydroxypyrazole 1 into the corresponding 2-alkyl-pyrazole-1-oxides 2a-f has been achieved by treatment with alkyl bromides in the absence of base. Subsequent deoxygenation/halogenation into 1-alkyl-5-halopyrazoles 3a-d and 4a-d using phosphorus oxyhalides is described.
2-Substituted Pyrazole 1-Oxides. Preparation and Reaction with Electrophilic Reagents
Begtrup, Mikael,Larsen, Peter,Vedsoe, Per
, p. 972 - 980 (2007/10/02)
1-Substituted pyrazoles have been oxidized by peracids to 2-substituted pyrazole 1-oxides.This leads to a change in reactivity towards electrophilic attack. 2-Benzylpyrazole 1-oxide is brominated, chlorinated, and nitrated selectively at C-3.The 3-halo-su
