145165-04-4

Upstream product

• 69350-48-7 (1S,3S,6R)-6-((1E,3Z)-5-Hydroxy-3-methyl-penta-1,3-dienyl)-1,5,5-trimethyl-7-oxa-bicyclo[4.1.0]heptan-3-ol 
• 509095-00-5 (1R,2S,4S)-4-tert-butyldimethylsiloxy-1,2-epoxy-2,6,6-trimethylcyclohexane-1-carbaldehyde 
• 509094-99-9 [(1S,4S,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-2,2,6-trimethyl-7-oxa-bicyclo[4.1.0]hept-1-yl]-methanol 
• 214335-71-4 (-)-[(S)-4-(tert-butyldimethylsilyloxy)-2,6,6-trimethylcyclohex-1-enyl]methanol 
• 69350-46-5 (2Z,4E)-5-((1R,4S,6S)-4-Hydroxy-2,2,6-trimethyl-7-oxa-bicyclo[4.1.0]hept-1-yl)-3-methyl-penta-2,4-dienoic acid methyl ester 

Relevant academic research and scientific papers

Stereocontrolled syntheses of carotenoid oxidative metabolites, (-)-loliolide, (-)-xanthoxin, and their stereoisomers

We achieved the stereocontrolled syntheses of (-)-loliolide, (-)-xanthoxin, and their stereoisomers from (+)- or (-)-3-alkoxy-6-hydroxymethyl-1,1,5-trimethylcyclohexene through the corresponding syn and anti-epoxides, respectively, which were obtained by utilizing the highly diastereoselective Sharpless asymmetric epoxidation or mCPBA oxidation.