145166-04-7

Basic information

• Product Name: Cycloheptanol, 2-amino-, (1S,2S)- (9CI)
• Synonyms: (1S,2S)-trans-2-Aminocycloheptanol;Cycloheptanol, 2-amino-, (1S,2S)- (9CI)
• CAS NO: 145166-04-7
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• Product Categories: AMINEPRIMARY
• Mol File: 145166-04-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 222.3±33.0 °C(Predicted)
• Appearance: /
• Density: 1.003±0.06 g/cm3(Predicted)
• PKA: 14.95±0.40(Predicted)
• BRN: 5805054
• CAS DataBase Reference: Cycloheptanol, 2-amino-, (1S,2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cycloheptanol, 2-amino-, (1S,2S)- (9CI)(145166-04-7)
• EPA Substance Registry System: Cycloheptanol, 2-amino-, (1S,2S)- (9CI)(145166-04-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 145166-04-7(Hazardous Substances Data)

Upstream product

• 285-67-6 Cyclopentene oxide 
• 932-57-0 (+/-)-trans-2-aminocycloheptanol 
• 628-92-2 Cycloheptene 
• 125356-53-8 (1S,2S)-trans-2-azidocycloheptanol 
• 145414-88-6 (1S,2S)-2-<(S)-(α-methylbenzyl)amino>cycloheptanol hydrochloride 
• 100723-47-5 (+/-)-4-nitro-benzoic acid-(trans-2-hydroxy-cycloheptylamide) 
• 111474-32-9 (+/-)-2-(4-nitro-phenyl)-(3ar,8ac)-4,5,6,7,8,8a-hexahydro-3aH-cyclohePtoxazole 
• 286-45-3 8-oxabicyclo[5.1.0]octane 
• 76519-87-4 (1R,7S)-cycloheptene oxide 

Downstream Products

• 932-57-0 (+)-#trans-2-amino-cycloheptanol 
• 932-57-0 (-)-#trans1-2-amino-cycloheptanol 
• 415693-38-8 (1R,2S)-2-(p-dimethylaminobenzoyl)aminocycloheptanol 
• 286-44-2 8-azabicyclo[5.1.0]octane 
• 2043-61-0 cyclohexanecarbaldehyde 
• 108248-85-7 (+/-)-2-phenyl-(3ar,8at)-4,5,6,7,8,8a-hexahydro-3aH-cyclohePtoxazole 

Relevant articles and documents

Lipase-catalyzed Kinetic Resolution of (+/-)-trans- and cis-2-Azidocycloalkanols

The lipase-catalyzed kinetic resolution of trans- and cis-2-azidocycloalkanols and the preparation of enantiomerically pure trans- and cis-2-aminocycloalkanols are described. Four kinds of lipases were screened for the acetylation of trans- and cis-2-azidocycloalkanols. Among them, Pseudomonas sp. lipases (lipase PS and lipase AK, Amamo Pharmaceutical Co.) showed the highest enantioselectivity. These products were converted to the corresponding 2-aminocycloalkanols to determine their enantiomeric excess (ee) and absolute configurations by HPLC and CD analyses, using (S)-TBMB carboxylic acid [(S)-2-tert-butyl-2-methyl-1,3-benzodioxole-4-carboxylic acid] as the chiral conversion reagent. The results of the CD analysis proved N,O-bis-(S)-TBMB carboxylated cis-2-aminocycloalkanols to adopt a predominantly N-equatorial conformation. The partially resolved trans- and cis-2-aminocycloalkanols, except for trans-2-aminocyclopentanol, were recrystallized from ethyl acetate to give enantiomerically pure forms.

CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS

This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted there on a primary amine and which is further linked or bridged to two mono- and/or bicyclic rings and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention

Compounds with Bridgehead Nitrogen. Part 43. The Reaction between trans-2-Aminocycloalkanethiols and Formaldehyde

trans-2-Aminocyclopentanethiol condenses with formaldehyde to give rel-(3aR,6aR,9aR,12aR)-6,12-methanoperhydrodicyclopentanodithiadiazecine, whereas trans-2-aminocyclohexanethiol and trans-2-aminocycloheptanethiol give 1:1 mixture of diastereomeric bis(perhydrocycloalkanothiazol-3-yl)methanes.