1451992-80-5Relevant articles and documents
Synthesis of a novel 1,2-dithianenucleoside via Pummerer-like reaction, followed by Vorbruggen glycosylation between a 1,2-dithiane derivative and uracil
Miyazawa, Tadashi,Umezaki, Kouhei,Tarashima, Noriko,Furukawa, Kazuhiro,Ooi, Takashi,Minakawa, Noriaki
, p. 7851 - 7853 (2013)
The novel 1,2-dithianenucleoside was designed as a hybrid type of modification between 4′-thioribonucleoside and altritol nucleoside. The desired compound, i.e., 1-[(3R,4R,5S,6R)-4,5-dihydroxy-6-hydroxymethyl-1,2- dithianyl]uracil (20), was prepared via the Pummerer-like reaction, followed by Vorbruggen glycosylation between an appropriately protected 1,2-dithiane derivative and silylated uracil.