331625-80-0Relevant articles and documents
Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC
Madern, Jerre M.,Kim, Robbert Q.,Misra, Mohit,Dikic, Ivan,Zhang, Yong,Ovaa, Huib,Codée, Jeroen D. C.,Filippov, Dmitri V.,van der Heden van Noort, Gerbrand J.
, p. 2903 - 2907 (2020/06/26)
Stable NAD+ analogues carrying single atom substitutions in either the furanose ring or the nicotinamide part have proven their value as inhibitors for NAD+-consuming enzymes. To investigate the potential of such compounds to inhibit
Chemistry and biology of khafrefungin. Large-scale synthesis, design, and structure-activity relationship of khafrefungin, an antifungal agent
Nakamura, Masayuki,Mori, Yuichiro,Okuyama, Kennichi,Tanikawa, Kunihiro,Yasuda, Satoshi,Kanada, Kentaro,Kobayashi, Shu
, p. 3362 - 3376 (2007/10/03)
Large-scale synthesis, design, and structure-activity relationships of khafrefungin are reported. Khafrefungin is an antifungal agent that inhibits inositol phosphorylceramide (IPC) synthase, a enzyme involved in fungal sphingolipid biosynthesis. Unlike o
An improved large scale synthesis of 1,4-anhydro-4-thio-D-ribitol
Minakawa, Noriaki,Kato, Yuka,Uetake, Koichi,Kaga, Daisuke,Matsuda, Akira
, p. 1699 - 1702 (2007/10/03)
An improved large scale synthesis of 1,4-anhydro-4-thio-D-ribitol (4) from D-ribose has been accomplished by combining the O-allyl and O-p-methoxybenzyl protecting groups. Compound 4 was obtained in 31% yield in eight steps with three chromatographic sepa
Total synthesis and structural elucidation of khafrefungin
Wakabayashi,Mori,Kobayashi
, p. 1372 - 1375 (2007/10/03)
Total synthesis and structural elucidation of khafrefungin, a novel antifungal agent isolated from the fermentation culture MF6020, have been achieved. Unlike other inhibitors that inhibit the corresponding enzyme in fungi and mammals to the same extent,