1451998-23-4

Upstream product

• 100-59-4 phenylmagnesium chloride 
• 100-58-3 phenylmagnesium bromide 
• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 398489-25-3 tert-butyl 3-hydroxy-3-phenylazetidine-1-carboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 1451998-24-5 3-methoxy-3-phenylazetidine trifluoroacetate 
• 1451993-03-5 (5-amino-3,4-dimethylthieno[2,3 c]pyridazin-6-yl)(3-methoxy-3-phenylazetidin-1-yl)methanone 

Relevant academic research and scientific papers

Chemodivergent and Stereoselective Access to Fused Isoxazoline Azetidines and Thietanes through [3 + 2]-Cycloadditions

By combining efficient methodologies for the preparation of substituted azetines and thietes with a highly regio- and diastereoselective [3 + 2]-cycloaddition, a straightforward pathway for the synthesis of fused isoxazoline azetidines and thietanes has been designed. With minimal steps and starting from commercial sources, a new library of elaborated architectures was synthesized opening up a new class of molecules with large potential in pharmacology. Finally, a retro [2 + 2]-cycloaddition leading to substituted isoxazoles is described.

Methods for the Synthesis of Substituted Azetines

Spurred on by the recent emerging interest from the chemical community for unsaturated four-membered heterocycles, an unprecedented approach to nitrogen-containing four-membered rings has been designed. 3,4-Disubstituted 2-azetines were synthesized from c

Regiodivergent Stereoselective Access to Fused Alkylideneazetidines

Following recent advances in the generalization and simplification of 2H-azetine synthesis, a regiodivergent approach to fused 2- and 3-alkylideneazetines was designed via the intermediate formation of unprecedented vinylazetine structures. Concise sequen

Stereoselective Access to Azetidine-Based α-Amino Acids and Applications to Small Peptide Synthesis

Non-natural azetidine-based amino acids (Aze) present interesting features in protein engineering. A simple organometallic route toward unsaturated carboxylic acid precursors is presented. Subsequent metal-catalyzed asymmetric reduction allowed for the sy

SUBSTITUTED 5-AMINOTHIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6- carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.