145208-86-2

Basic information

• Product Name: Pyrimidine, 2-(4-methyl-1-piperazinyl)- (9CI)
• Synonyms: Pyrimidine, 2-(4-methyl-1-piperazinyl)- (9CI);2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE;2-(4-methyl-1-piperazinyl)Pyrimidine
• CAS NO: 145208-86-2
• Molecular Formula: C₉H₁₄N₄
• Molecular Weight: 178.23426
• Product Categories: PIPERIDINE
• Mol File: 145208-86-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Pyrimidine, 2-(4-methyl-1-piperazinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-(4-methyl-1-piperazinyl)- (9CI)(145208-86-2)
• EPA Substance Registry System: Pyrimidine, 2-(4-methyl-1-piperazinyl)- (9CI)(145208-86-2)

Safety Data

• Hazardous Substances Data: 145208-86-2(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 2-(4-methyl-1-piperazinyl)- (9CI) is a chemical compound with the molecular formula C9H14N4. It is a derivative of pyrimidine and contains a piperazine ring with a methyl group attached to it. Pyrimidine, 2-(4-methyl-1-piperazinyl)- (9CI) is commonly used in pharmaceutical research and drug development as a potential therapeutic agent for various medical conditions. Its precise pharmacological properties and potential applications are the subject of ongoing research and investigation. The compound's structure and properties make it a promising candidate for further study and potential use in the development of novel drugs.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 1722-12-9 2-chloropyrimidine 
• 557-01-7 2-hydroxypyrimidine 
• 67-56-1 methanol 
• 20980-22-7 N-(2-pyridinyl)piperazine 
• 50-00-0 formaldehyd 
• 1015484-22-6 1-methyl-4-((trifluoro-λ⁴-boranyl)methyl)piperazine potassium 
• 4595-60-2 2-bromopyrimidine 

Downstream Products

• 3605-01-4 piribedil 
• 88268-16-0 2-(4-formyl-1-piperazinyl)primidine 

Relevant articles and documents

Vibrational spectrum of buspirone

The IR and Raman spectra of buspirone and buspirone hydrochloride were recorded in KBr pellets and chloroform solutions. Most of the vibrational bands were assigned to normal modes using quantum mechanical semiempirical and ab initio restricted Hartree-Fock (RHF) calculations on model systems. The essential spectral characteristics can be obtained from the analysis of three building blocks of buspirone, i.e. pyrimidine-piperazine, butyl spacer and imide residues. The spectral regions particularly sensitive to intermolecular interactions were identified. The theoretical calculations suggest that the 'NH+' band in buspirone hydrochloride reflects the formation of a moderately strong hydrogen bond between the protonated piperazine nitrogen atom (bound to the butyl spacer) and the chlorine anion.

Commercial Pd/C-Catalyzed N-Methylation of Nitroarenes and Amines Using Methanol as Both C1 and H2 Source

Herein, we report commercially available carbon-supported-palladium (Pd/C)-catalyzed N-methylation of nitroarenes and amines using MeOH as both a C1 and a H2 source. This transformation proceeds with high atom-economy and in an environmentally friendly way via borrowing hydrogen mechanism. A total of >30 structurally diverse N-methylamines, including bioactive compounds, were selectively synthesized with isolated yields of up to 95%. Furthermore, selective N-methylation and deuteration of nimesulide, a nonsteroidal anti-inflammatory drug, were realized through the late-stage functionalization.

Aminomethylation via cyclopalladated-ferrocenylimine-complexes-catalyzed Suzuki-Miyaura coupling of aryl halides with potassium N, N - dialkylaminomethyltrifluoroborates

Using cyclopalladated ferrocenylimine complexes (1-3 mol%) as catalysts, the Suzuki-Miyaura coupling of potassium N,N-dialkylaminomethyltrifluoroborates with aryl and heteroaryl halides were carried out in a 10:1 THF-H2O mixture at 80° in the presence of Cs2CO3 (3.0 equiv) as base, giving the desired cross-coupling products in 14-87% yields. A variety of potassium alkyltrifluoroborates were also examined. Georg Thieme Verlag Stuttgart New York.