145223-79-6Relevant academic research and scientific papers
3-Aminopyrrolidine lithium amide in enantioselective: Addition of organolithium compounds onto aromatic aldehydes
Corruble, Aline,Valnot, Jean-Yves,Maddaluno, Jacques,Duhamel, Pierre
, p. 1519 - 1523 (2007/10/03)
New N,N'-disubstituted-3-aminopyrrolidines lithium amides have been used as chiral auxiliaries in the asymmetric condensation of n-butyllithium onto aromatic aldehydes, leading to e.e.s up to 73%.
Handy access to chiral N,N'-disubstituted 3-aminopyrrolidines
Maddaluno,Corruble,Leroux,Ple,Duhamel
, p. 1239 - 1242 (2007/10/02)
A new and rapid synthesis of (S)-3-aminopyrrolidines Z is proposed from N-protected (S)-Asparagine. Basic cyclization of methyl N-Z-(S)-Asparaginate 1 followed by one-pot N-benzylation directly leads to (S)-aminosuccinimide 3 which, after cleavage of the
