145240-82-0

Upstream product

• 50-00-0 formaldehyd 
• 56613-80-0 D-2-phenylglycinol 
• 868-85-9 Dimethyl phosphite 
• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 145240-95-5 [1-((R)-2-Hydroxy-1-phenyl-ethylamino)-2-phenyl-ethyl]-phosphonic acid dimethyl ester 
• 145240-89-7 [2-Phenyl-1-((R)-4-phenyl-oxazolidin-3-yl)-ethyl]-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of α-amino phosphonic acids by diastereoselective addition of trimethyl phosphite onto chiral oxazolidines

A simple and general asymmetric synthesis of α-amino phosphonic acids is described. The method involves the highly selective addition of trialkyl phosphite onto various chiral oxazolidines. Oxazaphosphorinanes thus obtained with an excellent diastereoselectivity furnish the corresponding (S)-α-substituted amino phosphonic acids in good overall yields and high ee (77→97%) after simple deprotection.

A simple and general method for the asymmetric synthesis of α-aminophosphonic acids

A simple and general method for the asymmetric synthesis of α-aminophosphonic acids is described. A chiral phosphonate prepared in one step from R-(-)-phenylglycinol was alkylated with good diastereoselectivity using different electrophiles.