1452402-93-5Relevant academic research and scientific papers
Preparation of new alkyne-modified ansamitocins by mutasynthesis
Harmrolfs, Kirsten,Mancuso, Lena,Drung, Binia,Sasse, Florenz,Kirschning, Andreas
, p. 535 - 543 (2014/04/17)
The preparation of alkyne-modified ansamitocins by mutasynthetic supplementation of Actinosynnema pretiosum mutants with alkyne-substituted aminobenzoic acids is described. This modification paved the way to introduce a thiol linker by Huisgen-type cycloaddition which can principally be utilized to create tumor targeting conjugates. In bioactivity tests, only those new ansamitocin derivatives showed strong antiproliferative activity that bear an ester side chain at C-3.
Bioreduction of aryl azides during mutasynthesis of new ansamitocins
Mancuso, Lena,Juerjens, Gerrit,Hermane, Jekaterina,Harmrolfs, Kirsten,Eichner, Simone,Fohrer, Joerg,Collisi, Wera,Sasse, Florenz,Kirschning, Andreas
, p. 4442 - 4445 (2013/09/24)
Supplementing a culture of a mutant strain of Actinosynnema pretiosum that is unable to biosynthesize aminohydroxy benzoic acid (AHBA), with 3-azido-5-hydroxy-benzoic acid and 3-azido-5-amino-benzoic acid, unexpectedly yielded anilino ansamitocins instead
