145241-76-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
7,8-Difluoroquinoline is used as a key intermediate in the synthesis of various pharmaceutical drugs and agrochemicals, contributing to the development of new and effective treatments and products.
Used in Fluorescent Probe Applications:
7,8-Difluoroquinoline is used as a fluorescent probe in biological and environmental studies, owing to its strong fluorescence properties. This allows for its use in tracking and analyzing various biological processes and environmental conditions.
Used in Material Development:
7,8-Difluoroquinoline is utilized in the development of new materials, taking advantage of its chemical properties to create innovative and improved materials for various applications.
Used in Organic Synthesis:
As a building block in organic synthesis, 7,8-Difluoroquinoline is used to construct complex organic molecules, facilitating the creation of new compounds with potential applications in various industries.

InChI:InChI=1/C9H5F2N/c10-7-4-3-6-2-1-5-12-9(6)8(7)11/h1-5H

Upstream product

• 4519-40-8 2,3-difluoroanilline 
• 56-81-5 glycerol 

Downstream Products

• 1314012-52-6 7,8-difluoro-3-hydroxyquinoline 
• 1314012-54-8 7,8-difluoro-3-iodoquinoline 
• 1686108-69-9 3-bromo-7,8-difluoroquinoline 
• 318685-41-5 7,8-difluoro-quinoline-3-carboxylic acid 
• 318685-32-4 3-amino-7,8-difluoroquinoline 

Relevant academic research and scientific papers

Effects of oligofluorine substitution on the mutagenicity of quinoline: A study with twelve fluoroquinoline derivatives

A total of 12 variously fluorinated derivatives of quinoline (Q) were tested for their mutagenicity in Salmonella typhimurium TA100 in the presence of S9 mix to investigate the structure-mutagenicity relationship in oligofluorinated quinolines. Nine of th

The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists

As part of an effort to identify 5-HT1A antagonists that did not possess typical arylalkylamine or keto/amido-alkyl aryl piperazine scaffolds, prototype compound 10a was identified from earlier work in a combined 5-HT 1A antagonist/SSRI program. This quinolyl-piperazinyl piperidine analogue displayed potent, selective 5-HT1A antagonism but suffered from poor oxidative metabolic stability, resulting in low exposure following oral administration. SAR studies, driven primarily by in vitro liver microsomal stability assessment, identified compound 10b, which displayed improved oral bioavailability and lower intrinsic clearance. Further changes to the scaffold (e.g., 10r) resulted in a loss in potency. Compound 10b displayed cognitive enhancing effects in a number of animal models of learning and memory, enhanced the antidepressant-like effects of the SSRI fluoxetine, and reversed the sexual dysfunction induced by chronic fluoxetine treatment.

NITROGENATED HETEROCYCLIC COMPOUND AND AGRICULTURAL OR HORTICULTURAL FUNGICIDE

An agricultural or horticultural fungicide contains as an active ingredient thereof at least one compound selected from the group consisting of nitrogenated heterocyclic compounds represented by formula (I) (wherein, R represents a group represented by CR

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND AGRICULTURAL FUNGICIDE

Provided is an agricultural fungicide that contains at least one selected from the group consisting of a novel nitrogen-containing heterocyclic compound represented by Formula (I), a salt thereof, or an N-oxide compound thereof. In Formula (I), R represen

Piperazine-piperidine antagonists and agonists of the 5-HT1A receptor

The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT1A binding agents, particularly as 5-HT1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction.